Products with Cytotoxic bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN6568 | Norglaucine hydrochloride |
| 1.(+)-Norglaucine shows cytotoxic activity toward the tumor cell lines B16-F10 (mouse melanoma), HepG2 (human hepatocellular carcinoma), K562 (human chronic myelocytic leukemia) and HL-60 (human promyelocytic leukemia) and non-tumor peripheral blood mononuclear cells (PBMCs). | |
| BCN6573 | 6-Deoxyjacareubin |
| 1. 6-Deoxyjacareubin, 1,5-dihydroxyxanthone, and 5-hydroxy-1-methoxyxanthoneis are antifungal against Cladosporium cucumerinum, while they show differing degrees of inhibition of monoamine oxidase A and B. 2. 6-Deoxyjacareubin shows strong platelet activating factor (PAF) receptor binding inhibitory effects using rabbit platelets with IC50 values of 29.0 microM, suggests that xanthones can represent a new class of natural PAF receptor antagonists. 3. 6-Deoxyjacareubin possesses significant antioxidant activities. 4. 6-Deoxyjacareubin exhibits the cytotoxic activities against HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines. | |
| BCN6579 | Xanthoxyletin |
| 1. Xanthoxyletin shows cytotoxic activity, it can inhibit the incorporation of tritiated thymidine into human leukaemia (HL-60) cells. 2. Xanthoxyletin induces S phase arrest and apoptosis in human gastric adenocarcinoma SGC-7901 cells, the effects are associated with the DNA damage, apoptosis through mitochondrial dysfunction, and cell cycle arrest at S phase in a dose-dependent manner, it also can increase the production of reactive oxygen species, suggest that xanthoxyletin may be promising anticancer agent. 3. Xanthoxyletin shows anti-inflammatory activities, it shows an inhibitory effect on iNOS protein expression at 10 microM, it also can inhibit the synthesis of nitric oxide and the protein expression of tumor necrosis factor-alpha and cyclooxygenase-2 . 4. Xanthoxyletin shows potent antibacterial, fungicidal, and algicidal properties. | |
| BCN6623 | Scoulerine |
| 1. Scoulerine shows significant cytotoxic effects against both two cancer cell lines (Caco-2 and Hep-G2 cancer cells), with IC50 values 6.44 ± 0.87 and 4.57 ± 0.42, respectively. 2. Scoulerine shows antiplasmodial activity with IC(50) values of 5.4uM and 3.1uM against the antifolate sensitive and the multidrug resistant P. falciparum strains: TM4/8.2 and K1CB1, respectively. | |
| BCN6631 | 5,7-Dihydroxy-3-(4-hydroxy-3,5-dimethoxybenzyl)-6,8-dimethylchroman-4-one |
| 1. 5,7-Dihydroxy-3-(4-hydroxy-3,5-dimethoxybenzyl)-6,8-dimethylchroman-4-one has oxygen free radicals(OFRs) scavenging effects, it can scavenge hydroxyl radical(·OH) and hydrogen peroxide(H2O2) in vitro. 2. 5,7-Dihydroxy-3-(4-hydroxy-3,5-dimethoxybenzyl)-6,8-dimethylchroman-4-one shows a strong cytotoxic activity on HeLa-S3 cell. | |
