Products with Inhibitors bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN6564 | Neolinine |
| 1.Neolinine(at 10uM) shows significant hERG K+ channel inhibition activity. | |
| BCN6566 | Puerol A |
| 1. Puerol A exhibits potent inhibitory effects on aldose reductase with IC50 values of 6.4 uM. 2. dl-Puerol A has antioxdiant activity, it shows inhibitory effects on copper ion-induced protein oxidative modification of mouse brain homogenate in vitro. | |
| BCN6567 | Cycloshizukaol A |
| 1.Cycloshizukaol A prevents monocyte adhesion to HUVEC through the inhibition of cell adhesion molecules expression stimulated by TNF-alpha, it inhibits PMA-induced homotypic aggregation of HL-60 cells without cytotoxicity with MIC values of 0.9 microM. | |
| BCN6591 | 1-Methyl-2-undecylquinolin-4(1H)-one |
| 1. 1-Methyl-2-undecyl-4(1H)-quinolone(1-Methyl-2-undecylquinolin-4(1H)-one) shows a selective inhibition of type B MAO (MAO-B) activity with the IC(50) value of 15.3 microM using a substrate kynuramine, but does not inhibit type A MAO (MAO-A) activity. 2. 1-Methyl-2-undecyl-4(1H)-quinolone, and dihydroevocarpine should also be served as the chemical markers together with evodiamine for the quality control of Evodia rutaecarpa (Juss.) Benth. 3. 1-Methyl-2-undecyl-4(1H)-quinolone can mitigate high phosphate-induced human aortic valve interstitial cells (HAVICs) calcification by inhibiting phosphate cotransporter (PiT-1) gene expression. 4. 1-Methyl-2-undecyl-4(1H)-quinolone shows moderate antiangiogenic activity against human tumor cells. | |
| BCN6611 | Torilin |
| 1. Torilin has anti-inflammatory properties, it inhibits inflammation by limiting TAK1-mediated MAP kinase and NF-κB activation. 2. Torilin can attenuate arthritis severity, modify leukocyte activations in dLNs or joints, and restore serum and splenocyte cytokine imbalances, it may have immunomodulatory and anti-inflammatory properties with the capacity to ameliorate the inflammatory response in collagen-induced-arthritis-(CIA)-mice. 3. Torilin inhibits melanin production in alpha-melanocyte stimulating hormone-activated B16 melanoma cells, with an IC(50) value of 25 microM. 4. Torilin shows excellent antimicrobial activity against Bacillus subtilis ATCC 6633 spores and vegetative cells, it functions as a surfactant with hydrophilic and hydrophobic properties related to denaturalization of various proteins,the distortion of coat proteins due to direct binding polar groups of spore coats with hydrophilic groups of torilin may be responsible for the observed rapid inactivation of bacterial spores. 5. Torilin has a potent anti-angiogenic activity both in vivo and in vitro, and it may have a strong activity to suppress tumorigenesis by inhibition of tumor invasion. 6. Torilin is an inhibitor of testosterone 5 alpha-reductase, it (IC50 = 31.7 +/- 4.23 microM) shows a stronger inhibition of 5 alpha-reductase than alpha-linolenic acid (IC50 = 160.3 +/- 24.62 microM) but is weaker than finasteride (IC50 = 0.38 +/- 0.06 microM). 7. Torilin reverses multidrug-resistance in cancer cells, it can potentiate the cytotoxicities of adriamycin, vinblastine, taxol and colchicine against multidrug-resistant KB-V1 and MCF7/ADR cells. 8. Torilin and torilolone show hepatoprotective effects on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells, the EC50 values are 20.6 +/- 1.86 and 3.6 +/- 0.1 microM, respectively; and silybin as a positive control shows an EC50 value of 69.0 +/- 3.4 microM. | |
