NeolinineCAS# 112515-37-4 |
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| Cas No. | 112515-37-4 | SDF | Download SDF |
| PubChem ID | 137346018 | Appearance | Powder |
| Formula | C23H37NO6 | M.Wt | 423.6 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (2R,3R,4S,5S,6S,8R,13S,16S,17R,18R)-11-ethyl-13-(hydroxymethyl)-6,18-dimethoxy-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecane-4,8,16-triol | ||
| SMILES | CCN1CC2(CCC(C34C2C(C(C31)C5(CC(C6CC4C5C6O)OC)O)OC)O)CO | ||
| Standard InChIKey | RQCXQGUVPFYJCE-LDIBJOKXSA-N | ||
| Standard InChI | InChI=1S/C23H37NO6/c1-4-24-9-21(10-25)6-5-14(26)23-12-7-11-13(29-2)8-22(28,15(12)17(11)27)16(20(23)24)18(30-3)19(21)23/h11-20,25-28H,4-10H2,1-3H3/t11-,12-,13+,14+,15-,16?,17+,18+,19-,20?,21+,22-,23?/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The roots of Aconitum pseudostapfianum W. T. Wang
| Description | 1.Neolinine(at 10uM) shows significant hERG K+ channel inhibition activity. |
| Targets | Potassium Channel |
Neolinine Dilution Calculator
Neolinine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.3607 mL | 11.8036 mL | 23.6072 mL | 47.2144 mL | 59.0179 mL |
| 5 mM | 0.4721 mL | 2.3607 mL | 4.7214 mL | 9.4429 mL | 11.8036 mL |
| 10 mM | 0.2361 mL | 1.1804 mL | 2.3607 mL | 4.7214 mL | 5.9018 mL |
| 50 mM | 0.0472 mL | 0.2361 mL | 0.4721 mL | 0.9443 mL | 1.1804 mL |
| 100 mM | 0.0236 mL | 0.118 mL | 0.2361 mL | 0.4721 mL | 0.5902 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Diterpene alkaloids from Aconitum anthora and assessment of the hERG-inhibiting ability of Aconitum alkaloids.[Pubmed:20862641]
Planta Med. 2011 Mar;77(4):368-73.
A new norditerpene alkaloid, 10-hydroxy-8- O-methyltalatizamine (1), was isolated from the whole plant of ACONITUM ANTHORA L. besides the known isotalatizidine (2) and hetisinone (3). The structures were determined by means of HR-ESI-MS, 1D and 2D NMR spectroscopy, including (1)H-(1)H COSY, NOESY, HSQC and HMBC experiments, resulting in complete (1)H and (1)(3)C chemical shift assignments for 1- 3, and revision of some earlier (1)(3)C-NMR data. The effects of the isolated compounds, together with twenty-one other ACONITUM alkaloids with different skeletal types and substitution patterns, on hERG channels were studied by the whole-cell patch clamp technique, using the QPatch-16 automated patch clamp system. At 10 microM, aconitine, 14-benzoylaconine 8- O-palmitate, songoramine, gigactonine and Neolinine demonstrated significant hERG K+ channel inhibition; all other compounds exerted only low (6-21%) inhibitory activity.
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