Products with Inhibitors bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN3846 | Sotetsuflavone |
| 1. Sotetsuflavone , with an IC50 = 0.16 μM, is the most active compound of this series and is the strongest inhibitor of the Dengue virus NS5 RNA-dependent RNA polymerase . | |
| BCN3855 | Alpha-pinene |
| Alpha-pinene inhibits the nuclear translocation of NF-kappa B induced by LPS in THP-1 cells, and this effect is partly due to the upregulation of I kappa B alpha expression. Alpha-pinene inhibits early root growth and causes oxidative damage in root tissue through enhanced generation of ROS, as indicated by increased lipid peroxidation, disruption of membrane integrity and elevated antioxidant enzyme levels. | |
| BCN3884 | Brevifolincarboxylic acid |
| 1. Brevifolincarboxylic acid shows marked inhibitory effects on aryl hydrocarbon receptor -based bioassay activation by TCDD, and its effect is dose dependent. 2. Brevifolincarboxylic acid (IC50 = 18.0 uM) shows good antioxidant activity. 3. Brevifolincarboxylic acid shows moderate antibacterial activity against Salmonella enteritidis , Salmonella typhimurium , and Salmonella abony. | |
| BCN3886 | Gitogenin |
| 1. Gitogenin, tigogenin, and solasodine are novel selective inhibitors of UGT1A4, and do not inhibit the activities of major human CYP isoforms. 2. Gitogenin and (25S)-5α-furastan-3β,22,26-triol are the inhibitors of enzyme α-glucosidase with IC50 values of 37.2±0.18 and 33.5±0.22 uM, respectively. 3. Gitogenin shows moderate stimulation of release activity on growth hormone from rat pituitary cells. | |
| BCN3894 | Gliotoxin |
| 1. Gliotoxin targets nuclear NOTCH2 in human solid tumor derived cell lines in vitro and inhibits melanoma growth in xenograft mouse model. 2. Gliotoxin exhibits very strong anti-tuberculosis activity towards Mycobacterium tuberculosis with the the prominent MIC50 value of <0.03 uM. 3. Gliotoxin displays significant selective cytotoxicities against K562, A549 and Huh-7 cell lines with the IC50 values of 0.191, 0.015 and 95.4 uM, respectively. 4. Gliotoxin suppresses macrophage immune function by subverting phosphatidylinositol 3,4,5-trisphosphate homeostasis. 5. Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signaling pathway. | |
