Products with Inhibitors bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN3055 | Kuguacin J |
| 1. Kuguacin J exerts growth inhibition through G1 arrest and induction of apoptosis in androgen-dependent human prostate cancer, it is a promising candidate new antineoplastic and chemopreventive agent for androgen-dependent prostate cancer and carcinogenesis. 2. Kuguacin J modulates the function of P-glycoprotein (P-gp) by directly interacting at the drug-substrate-binding site, and it appears to be an effective inhibitor of P-gp activity in vitro and thus could be developed as an effective chemosensitizer to treat multidrug-resistant cancers. | |
| BCN3105 | 9-Hydroxycanthin-6-one |
| 1. 9-Hydroxycanthin-6-one inhibits Wnt signaling through the activation of GSK3β independent of CK1α. 2. 9-Hydroxycanthin-6-one might be the active component that contributed to the aphrodisiac effect of E. longifolia by antagonizing the smooth muscle tone of CC as well as SV probably through interfering with Ca2+ mobilization. | |
| BCN3108 | Eurycomalactone |
| 1. Eurycomalactone displays potent activity against all the tested cell lines [colon 26-L5 carcinoma (IC50 = 0.70 microM), B16-BL6 melanoma (IC50 = 0.59 microM), Lewis lung carcinoma (IC50 = 0.78 microM), and a human lung A549 adenocarcinoma (IC50 = 0.73 microM)]. 2. Eurycomalactone as a potent NF-κB inhibitor with the IC50 value of less than 1 uM. 3. Eurycomalactone displays antiplasmodial activity against Gombak A isolate. | |
| BCN3123 | Tanshindiol A |
| 1. Tanshindiol A is potential xanthine oxidase. 2. Tanshindiol A has activity against cancer. 3. Tanshindiol A has activity against cardiovascular diseases. | |
| BCN3124 | Tanshindiol B |
| 1. Tanshindiol B is potential xanthine oxidase inhibitors. | |
