|
BCN5121 |
(+)-Afzelechin
|
|
1. (+)-Afzelechin has a neuroprotective effect on the glutamate-induced neurotoxicity in HT22 cells, it has ABTS cation radical scavenging effects with IC50 values of 23.7 microM, suggests that it could be neuroprotectants owing to their free radical scavenging activities.
2. (+)-Afzelechin has inhibitory compound of alpha-glucosidase activity, the ID(50) (50% inhibition dose) value is 0.13 mM.
3. (+)-Afzelechin shows moderate to strong radical scavenging properties against diphenylpicrylhydrazyl radical (DPPH) and improves the reduced glutathione levels in rat pancreatic homogenate. |
|
BCN5156 |
Oxysophocarpine
|
|
Oxysophocarpine shows anti-inflammatory, neuroprotective,
anticonvulsant, and anti-nociceptive effects, it also attenuates inflammatory pain by suppressing the levels of phosphorylation of extracellular signal-regulated kinase 1/2, cyclooxygenase-2, prostaglandin E2, tumor necrosis factor α, interleukin-1 beta and interleukin-6. |
|
BCN5178 |
Reynosin
|
|
1. Reynosin has hepatoprotective effects, it can inhibit thioacetamide-induced apoptosis in primary hepatocytes and an in vivo mouse model.
2. Reynosin has protective effect against dopamine-induced neuronal cell death, which may be due to the reciprocal up-regulation of E6-associated protein and down-regulation of α-synuclein protein expression.
3. Reynosin exhibits a dose-dependent inhibition on CINC-1 induction in LPS-stimulated NRK-52E cells, where 50% of inhibitory effect was shown at the concentration of about 1 microM.
4. Reynosin has strong anti-mycobactericidal activity, with a minimal bactericidal concentration (MBC) of 128ug/mL against the H37Rv, 366-2009 and 104-2010 Mtb strains and a minimal inhibitory concentration (MIC) of 64, 64, 128, 128 and 128ug/mL against the H37Rv, 104-2010, 63-2009, 366-2009 and 430-2010 Mtb strains, respectively.
5. Reynosin can inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-activated murine macrophages.
6. Reynosin shows cytotoxicity against the KB cancer cell line (ATCC CCL17), with IC50 value of 2.7 microg/mL.
7. Reynosin shows moderate anti-inflammatory activity, it exhibits a concentration-related decrease in the levels of IL-1β, IL-6, TNF-α, PGE2, lipoxgenase-5, and COX-2. |
|
BCN5201 |
Oxyresveratrol
|
|
Oxyresveratrol , a dietary phenolic compound, has neuroprotective effect, as a potential nutritional candidate for protection against neurodegeneration in Parkinson disease; Oxyresveratrol has antioxidant activity, can reduce neuronal oxidative damage and protect hepatocytes against oxidative stress and mitochondrial dysfunction, which may be associated with activation of Nrf2, it also as an antibrowning agent for cloudy apple juices and fresh-cut apples. Oxyresveratrol exhibits a potent inhibitory effect on dopa oxidase activity of tyrosinase which catalyzes rate-limiting steps of melanin biosynthesis.Oxyresveratrol exhibits the inhibitory activity at the early and late phase of viral replication and inhibited the viral replication with pretreatment in one-step growth assay of HSV-1 and HSV-2. |
|
BCN5232 |
Isobavachin
|
|
Isobavachin can stimulate osteoblasts proliferation and differentiation; it also can facilitate mouse embryonic stem cells differentiating into neuronal cells, the mechanism involved protein prenylation and, subsequently, phos-ERK activation and the phos-p38 off pathway. Isobavachin possesses estrogen-like activity in MCF-7/BOS cells, it can significantly stimulate the proliferation of MCF-7/BOS cells in a dose-dependent manner. Isobavachin has cytotoxic effects on H4IIE hepatoma and metabolically poorly active C6 glioma cells. |
