Products with Neuroprotection bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN4901 | Cannabichromene |
| 1. Cannabichromene is a major non-psychotropic phytocannabinoid that inhibits endocannabinoid inactivation and activates the transient receptor potential ankyrin-1 (TRPA1), it selectively reduces inflammation-induced hypermotility in vivo in a manner that is not dependent on cannabinoid receptors or TRPA1. 2. Cannabichromene exerts anti-inflammatory actions in activated macrophages with tonic CB1 cannabinoid signalling being negatively coupled to this effect and ameliorates experimental murine colitis. 3. Cannabichromene can raise the viability of neural stem progenitor cells (NSPCs), while inhibiting their differentiation into astroglia, possibly through up-regulation of ATP and adenosine signalling. | |
| BCN4911 | Berberine |
| Berberine has neuroprotective, antidepressant, antineoplastic, and anti- fibrosis activities; it is a potent oral hypoglycemic agent with beneficial effects on lipid metabolism, it may as a broad-spectrum anti-microbial medicine, a complementary therapeutic agent for HIV/AIDS; it also may be one of the targeted therapeutic agents that can restore barrier function in intestinal disease states.Berberine is used in histology for staining heparin in mast cells. As a natural dye, berberine has a colour index of 75160. | |
| BCN4953 | Echinacoside |
| Echinacoside is a natural polyphenolic compound, has various kinds of pharmacological activities, such as anti-senescence, anti-hypoxia, anti-cancer, anti-osteoporosis, antioxidative, anti-inflammatory, neuroprotective, hepatoprotective, nitric oxide radical-scavenging and vasodilative ones. Echinacoside can improve the hematopoietic function of bone marrow in 5-FU-induced myelosuppression mice, it induces apoptotic cancer cell death by inhibiting the nucleotide pool sanitizing enzyme MTH1. Echinacoside inhibits cytochrome c release and caspase-3 activation caused by ensuing rotenone exposure via activating Trk-extracellular signal-regulated kinase (ERK) pathway in neuronal cells. | |
| BCN4964 | Borneol |
| (+)-Borneol is a bicyclic monoterpene used for analgesia and anaesthesia in traditional Chinese and Japanese medicine, it and its enantiomer (-)-borneol have a highly efficacious positive modulating action at GABA(A) receptors at human recombinant alpha1beta2gamma2L GABA(A) receptors. Borneol specifically inhibits the nicotinic acetylcholine receptor (nAChR)-mediated effects in a noncompetitive way, can depress P-glycoprotein function by a NF-κB signaling mediated mechanism in a blood brain barrier in vitro model. Borneol has neuroprotection through the inhibition of IκBα-NF-κB and translocation signaling pathway, it also has an anti-cerebral ischemia effects. It can suppresse inflammatory responses in LPS-induced acute lung injury through inhibition of the NF-κB and MAPKs signaling pathways. | |
| BCN4966 | Patchouli alcohol |
| Patchouli alcohol has anti-inflammatory, neuroprotective, anti-cancer, anti-oxidant, gastroprotective, immunomodulatory, and antibacterial effects, which may be mediated, at least in part, by down-regulation of the mRNA expression of a panel of inflammatory mediators, such as TNF-α, IL-1β, IL-6, iNOS and COX-2. Patchouli alcohol significantly accelerates the recovery of the UV-induced skin lesions, evidently through anti-oxidant and anti-inflammatory action, as well as down-regulation of the MMP-1 and MMP-3 expression. | |
