Products with Neuroprotection bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN4725 | Sulfuretin |
| 1. Sulfuretin may have therapeutic value in preventing or delaying the progression of rheumatoid arthritis. 2. Sulfuretin has therapeutical effect on leukemia, due to its potent apoptotic activity through the extrinsic pathway driven by a Fas-mediated caspase-8-dependent pathway. 3. Sulfuretin is a potent anti-oxidant, has protective effect against t-BHP-induced oxidative damage in human liver-derived HepG2 cells is attributable to its ability to scavenge ROS and up-regulate the activity of HO-1 through the Nrf2/ARE and JNK/ERK signaling pathways. 4. Sulfuretin may have a potential role for neuroprotection, possibly through inhibition of phosphorylation of MAPK, PI3K/Akt, and GSK-3β, which leads to mitochondrial protection, NF-κB modulations and subsequent suppression of apoptosis via ROS-dependent pathwaysand, may be used as a therapeutic agent for PD. | |
| BCN4748 | Cedrin |
| 1. Cedrin has protective effects on PC12 cells against the neurotoxicity induced by amyloid β1-42, the protective effect is related to the inhibition of oxidative stress, improvement of mitochondrial dysfunction and suppression of apoptosis. | |
| BCN4846 | Sanggenon N |
| 1. Sanggenon N shows protective effects on t-BHP-induced oxidative stress with the EC50 value of 23.45 ± 4.72 uM. 2. Sanggenon N inhibits lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages. | |
| BCN4877 | Methyllucidone |
| 1. Methyllucidone may have a neuroprotective potential via inhibition of neurotoxic microglial activation implicated in neurodegeneration. 2. Methyllucidone can strongly inhibit the growth of human cancer cells and colon tumor xenografted in nude mice, the anti-tumor effects are further confirmed with caspase-3 activation and degradation of PARP. 3. Methyllucidone shows 85% antifungal activity at 50 against the disease wheat leaf rust. | |
| BCN4889 | Tiliroside |
| 1. Tribuloside can improve behavior and BrdU immunoreactive cells of depression model rats and possess antidepressant effect. 2. Tribuloside exhibits antimycobacterial activity against the non-pathogenic Mycobacterium species Mycobacterium madagascariense and Mycobacterium indicus pranii, with a minimum inhibitory concentration (MIC) 5.0 mg/mL . 3. Tribuloside has 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity.4. Tiliroside possesses anti-inflammatory, antioxidant, anti-complement, anti-diabetic, anticarcinogenic and hepatoprotective activities. Tiliroside enhances fatty acid oxidation via the enhancement adiponectin signaling associated with the activation of both AMP-activated protein kinase and peroxisome proliferator-activated receptor α and ameliorates obesity-induced metabolic disorders. | |
