Products with Neuroprotection Bioactivity

Explore BioCrick products associated with Neuroprotection biological activity, including catalog numbers, product names and available bioactivity information.

Cat. No.	Product Name
BCN4249	Sophoridine
Sophoridine has anti-inflammatory, anti-cancer and anti-arrhythmia, and affects the immune and central nervous systems. Early and short-time applying sophoridine has neuroprotective effect min permanent middle cerebral artery occlusion (pMCAO) rat brain by down-regulating TRAF6 and up-regulating p-ERK1/2 expression, ameliorating brain infaction and edema. Sophoridine also possesses antiviral activities against Coxsackievirus B3, by regulating cytokine expression, may represent a potential therapeutic agent for viral myocarditis.
BCN4261	4,10-Aromadendranediol
1. 4,10-Aromadendranediol exhibits neurite outgrowth-inducing activity in neurons via activation of the ERK signaling pathway, which may be beneficial to the treatment of brain diseases.
BCN4305	alpha-Tocopherolquinone
Alpha-Tocopherolquinone has antioxidant effect, can inhibit lipid peroxidation and reduce cell division in both the glioma cell clone and fetal brain cells； it inhibits β-amyloid aggregation and cytotoxicity, disaggregates preformed fibrils and decreases the production of reactive oxygen species, NO and inflammatory cytokines.
BCN4311	Morachalcone A
1. Morachalcone A exhibits neuroprotective effects on HT22-immortalized hippocampal cells against glutamate-induced oxidative stress, with EC50 values of 35.5±2.1 uM. 2. Morachalcone A exhibits potent inhibitory activity on nitric oxide production in RAW264.7 LPS-activated mouse macrophage cells with IC50 value of 16.4 microM. 3. Morachalcone A displays significant tyrosinase inhibitory activity (IC50, 0.013 uM). 4. Morachalcone A exerts strong pancreatic lipase inhibition with IC 50 value of 6.2 uM.
BCN4321	15-Methoxypinusolidic acid
1. 15-Methoxypinusolidic acid induced apoptosis in murine microglial cells, presumably via inhibition of the cell cycle progression. 2. 15-Methoxypinusolidic acid inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB, suggesting a potential anti-inflammatory effect of the compound on microglial cells. 3. 15-Methoxypinusolidic acid suppresses adipocyte differentiation through the inhibition of PPARgamma-dependent adipogenic gene expression. 4. 15-Methoxypinusolidic acid attenuates glutamate-induced excitotoxicity via stabilization of [Ca2+]i homeostasis and suppression of oxidative stress possibly through the actions on the NMDA receptors.

Neuroprotection Bioactivity Products