Cedrin

CAS# 75513-81-4

Cedrin

Catalog No. BCN4748----Order now to get a substantial discount!

Product Name & Size Price Stock
Cedrin: 5mg $903 In Stock
Cedrin: 10mg Please Inquire In Stock
Cedrin: 20mg Please Inquire Please Inquire
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Quality Control of Cedrin

Number of papers citing our products

Chemical structure

Cedrin

3D structure

Chemical Properties of Cedrin

Cas No. 75513-81-4 SDF Download SDF
PubChem ID 21721881 Appearance Powder
Formula C16H14O8 M.Wt 334.3
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (2R,3R)-3,5,7-trihydroxy-6-methyl-2-(3,4,5-trihydroxyphenyl)-2,3-dihydrochromen-4-one
SMILES CC1=C(C=C2C(=C1O)C(=O)C(C(O2)C3=CC(=C(C(=C3)O)O)O)O)O
Standard InChIKey NZRLODDQFPZTPM-JKSUJKDBSA-N
Standard InChI InChI=1S/C16H14O8/c1-5-7(17)4-10-11(12(5)20)14(22)15(23)16(24-10)6-2-8(18)13(21)9(19)3-6/h2-4,15-21,23H,1H3/t15-,16+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Cedrin

The herbs of Cedrus deodara

Biological Activity of Cedrin

Description1. Cedrin has protective effects on PC12 cells against the neurotoxicity induced by amyloid β1-42, the protective effect is related to the inhibition of oxidative stress, improvement of mitochondrial dysfunction and suppression of apoptosis.
TargetsBcl-2/Bax | Caspase | Beta Amyloid

Cedrin Dilution Calculator

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Cedrin Molarity Calculator

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Preparing Stock Solutions of Cedrin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.9913 mL 14.9566 mL 29.9133 mL 59.8265 mL 74.7831 mL
5 mM 0.5983 mL 2.9913 mL 5.9827 mL 11.9653 mL 14.9566 mL
10 mM 0.2991 mL 1.4957 mL 2.9913 mL 5.9827 mL 7.4783 mL
50 mM 0.0598 mL 0.2991 mL 0.5983 mL 1.1965 mL 1.4957 mL
100 mM 0.0299 mL 0.1496 mL 0.2991 mL 0.5983 mL 0.7478 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Cedrin

Cedrin identified from Cedrus deodara (Roxb.) G. Don protects PC12 cells against neurotoxicity induced by Abeta1-42.[Pubmed:28658984]

Nat Prod Res. 2018 Jun;32(12):1455-1458.

Alzheimer's disease is a severe neurodegenerative disease affecting elder worldwide and closely related to the neurotoxicity induced by amyloid beta. To find efficient therapeutics, we have investigated the protective effects of Cedrin from Cedrus deodara (Roxb.) G. Don on PC12 cells against the neurotoxicity induced by amyloid beta1-42. The results have shown the viability of PC12 cells injured by amyloid beta1-42 can be improved by Cedrin. Cedrin can reduce reacrive oxygen species overproduction, increase the activity of superoxide dismutase and decrease malondialdehyde content. Meanwhile, the loss of mitochondrial membrane potential and mitochondrial permeability transition pore opening in PC12 cells, and elevated Caspase-3 activity, downregulated Bcl-2 and upregulated Bax are meliorated. These results demonstrate the protective effect of Cedrin is related to the inhibition of oxidative stress, improvement of mitochondrial dysfunction and suppression of apoptosis. This investigation gives evidences for the application of Cedrin in practice and further investigation in vivo.

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