CedrinCAS# 75513-81-4 |
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 75513-81-4 | SDF | Download SDF |
| PubChem ID | 21721881 | Appearance | Powder |
| Formula | C16H14O8 | M.Wt | 334.3 |
| Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (2R,3R)-3,5,7-trihydroxy-6-methyl-2-(3,4,5-trihydroxyphenyl)-2,3-dihydrochromen-4-one | ||
| SMILES | CC1=C(C=C2C(=C1O)C(=O)C(C(O2)C3=CC(=C(C(=C3)O)O)O)O)O | ||
| Standard InChIKey | NZRLODDQFPZTPM-JKSUJKDBSA-N | ||
| Standard InChI | InChI=1S/C16H14O8/c1-5-7(17)4-10-11(12(5)20)14(22)15(23)16(24-10)6-2-8(18)13(21)9(19)3-6/h2-4,15-21,23H,1H3/t15-,16+/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The herbs of Cedrus deodara
| Description | 1. Cedrin has protective effects on PC12 cells against the neurotoxicity induced by amyloid β1-42, the protective effect is related to the inhibition of oxidative stress, improvement of mitochondrial dysfunction and suppression of apoptosis. |
| Targets | Bcl-2/Bax | Caspase | Beta Amyloid |
Cedrin Dilution Calculator
Cedrin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.9913 mL | 14.9566 mL | 29.9133 mL | 59.8265 mL | 74.7831 mL |
| 5 mM | 0.5983 mL | 2.9913 mL | 5.9827 mL | 11.9653 mL | 14.9566 mL |
| 10 mM | 0.2991 mL | 1.4957 mL | 2.9913 mL | 5.9827 mL | 7.4783 mL |
| 50 mM | 0.0598 mL | 0.2991 mL | 0.5983 mL | 1.1965 mL | 1.4957 mL |
| 100 mM | 0.0299 mL | 0.1496 mL | 0.2991 mL | 0.5983 mL | 0.7478 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
Featured Products
- Flupirtine maleate
Catalog No.:BCC4456
CAS No.:75507-68-5
- BI6727 (Volasertib)
Catalog No.:BCC3886
CAS No.:755038-65-4
- BI 2536
Catalog No.:BCC2081
CAS No.:755038-02-9
- Regorafenib
Catalog No.:BCC3646
CAS No.:755037-03-7
- N-Methylnuciferine
Catalog No.:BCN3971
CAS No.:754919-24-9
- CGP 37157
Catalog No.:BCC6943
CAS No.:75450-34-9
- Moxonidine
Catalog No.:BCC2142
CAS No.:75438-57-2
- EHT 1864
Catalog No.:BCC6075
CAS No.:754240-09-0
- Boc-Asp(OBzl)-OH
Catalog No.:BCC2608
CAS No.:7536-58-5
- Boc-Asn-OH
Catalog No.:BCC3071
CAS No.:7536-55-2
- Indacaterol Maleate
Catalog No.:BCC4358
CAS No.:753498-25-8
- Lovastatin
Catalog No.:BCN1060
CAS No.:75330-75-5
New Products
- Nilvadipine
Catalog No.:BCC3799
CAS No.:75530-68-6
- Moxonidine hydrochloride
Catalog No.:BCC5163
CAS No.:75536-04-8
- Dencichin
Catalog No.:BCN2555
CAS No.:7554-90-7
- Ingenol 3-Angelate
Catalog No.:BCN2961
CAS No.:75567-37-2
- 20-Deoxyingenol 3-angelate
Catalog No.:BCN6642
CAS No.:75567-38-3
- Sodium phosphate dibasic
Catalog No.:BCC7585
CAS No.:7558-79-4
- Sodium phosphate monobasic
Catalog No.:BCC8033
CAS No.:7558-80-7
- alpha-Tocopherolquinone
Catalog No.:BCN4305
CAS No.:7559-04-8
- Kaerophyllin
Catalog No.:BCN4304
CAS No.:75590-33-9
- Methyl 3,4,5-trimethoxycinnamate
Catalog No.:BCN4589
CAS No.:7560-49-8
- Fludarabine Phosphate (Fludara)
Catalog No.:BCC3681
CAS No.:75607-67-9
- (S)-(+)-α-Methylhistamine dihydrobromide
Catalog No.:BCC6700
CAS No.:75614-93-6
Cedrin identified from Cedrus deodara (Roxb.) G. Don protects PC12 cells against neurotoxicity induced by Abeta1-42.[Pubmed:28658984]
Nat Prod Res. 2018 Jun;32(12):1455-1458.
Alzheimer's disease is a severe neurodegenerative disease affecting elder worldwide and closely related to the neurotoxicity induced by amyloid beta. To find efficient therapeutics, we have investigated the protective effects of Cedrin from Cedrus deodara (Roxb.) G. Don on PC12 cells against the neurotoxicity induced by amyloid beta1-42. The results have shown the viability of PC12 cells injured by amyloid beta1-42 can be improved by Cedrin. Cedrin can reduce reacrive oxygen species overproduction, increase the activity of superoxide dismutase and decrease malondialdehyde content. Meanwhile, the loss of mitochondrial membrane potential and mitochondrial permeability transition pore opening in PC12 cells, and elevated Caspase-3 activity, downregulated Bcl-2 and upregulated Bax are meliorated. These results demonstrate the protective effect of Cedrin is related to the inhibition of oxidative stress, improvement of mitochondrial dysfunction and suppression of apoptosis. This investigation gives evidences for the application of Cedrin in practice and further investigation in vivo.
Cedrin,75513-81-4,Natural Products, buy Cedrin , Cedrin supplier , purchase Cedrin , Cedrin cost , Cedrin manufacturer , order Cedrin , high purity Cedrin
