Products with Pro-apoptotic bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN3692 | Sanggenol L |
| 1. Sanggenol L induces apoptosis via caspase activation and inhibition of NF-κB/IκBα phosphorylation as a potent chemotherapeutic agent for ovarian cancers. 2. Sanggenol L shows higher cytotoxicity against human oral tumor cell lines (HSC-2 and HSG) than against normal human gingival fibroblasts (HGF). | |
| BCN3725 | Beta-Tocotrienol |
| 1. Beta-Tocotrienol to serve as a new anticancer agent for treating human lung and brain cancers. 2. Beta-Tocotrienol inhibits the growth of both A549 (GI50=1.38±0.334μM) and U87MG (GI50=2.53±0.604μM) cells at rather low concentrations. | |
| BCN3783 | Euphorbia factor L2 |
| 1. Euphorbia factor L2 shows cytotoxic activity against lung carcinoma A549 cells, it induces apoptosis through a mitochondrial pathway. | |
| BCN3825 | 2,5-Dihydroxyacetophenone |
| 2,5-Dihydroxyacetophenone is an uncompetitive inhibitor of murine tyrosinase (K(I) 0.28mm), it strongly inhibits both melanogenesis and cellular tyrosinase activity, it possesses anti-inflammatoryanti-anxiety, and neuroprotective qualities. 2,5-Dihydroxyacetophenone treatment can induce a sustained activation of JNK, ERK1/2, and p38 MAPKs, it also can potentiate the pro-apoptotic and anti-proliferative effects of bortezomib in U266 cells. | |
| BCN3894 | Gliotoxin |
| 1. Gliotoxin targets nuclear NOTCH2 in human solid tumor derived cell lines in vitro and inhibits melanoma growth in xenograft mouse model. 2. Gliotoxin exhibits very strong anti-tuberculosis activity towards Mycobacterium tuberculosis with the the prominent MIC50 value of <0.03 uM. 3. Gliotoxin displays significant selective cytotoxicities against K562, A549 and Huh-7 cell lines with the IC50 values of 0.191, 0.015 and 95.4 uM, respectively. 4. Gliotoxin suppresses macrophage immune function by subverting phosphatidylinositol 3,4,5-trisphosphate homeostasis. 5. Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signaling pathway. | |
