Products with Pro-apoptotic bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN3933 | Paeoniflorigenone |
| 1. Paeoniflorigenone is a depolarizing neuromuscular blocking agent, being similar to succinylcholine. 2. Paeoniflorigenone is cytotoxic and induces apoptosis selectively in the cancer cell lines. 3. Paeoniflorigenone may take part in improving blood circulation by inhibiting ether platelet aggregation and/or blood coagulation. 4. Paeoniflorigenone shows anti-inflammatory effects. | |
| BCN3965 | Angophorol |
| 1. Angophorol exerts potential anticancer activity through growth inhibition and apoptosis in K562 cells. | |
| BCN3978 | Isoerysenegalensein E |
| 1. Isoerysenegalensein E shows significant cytotoxicity against HL-60 cells, it induces apoptosis in HL-60 cells through activation of the caspase-9/caspase-3 pathway, which is triggered by mitochondrial dysfunction. 2. Isoerysenegalensein E shows anti-estrogenic activity comparable to that of 4-hydroxytamoxifen, a typical estrogen receptor antagonist. | |
| BCN4321 | 15-Methoxypinusolidic acid |
| 1. 15-Methoxypinusolidic acid induced apoptosis in murine microglial cells, presumably via inhibition of the cell cycle progression. 2. 15-Methoxypinusolidic acid inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB, suggesting a potential anti-inflammatory effect of the compound on microglial cells. 3. 15-Methoxypinusolidic acid suppresses adipocyte differentiation through the inhibition of PPARgamma-dependent adipogenic gene expression. 4. 15-Methoxypinusolidic acid attenuates glutamate-induced excitotoxicity via stabilization of [Ca2+]i homeostasis and suppression of oxidative stress possibly through the actions on the NMDA receptors. | |
| BCN4329 | Longikaurin E |
| 1. Longikaurin E induces apoptosis of pancreatic cancer cells via ROS generation to modulate the p38 and PI3K/AKT pathways and could be a promising anti-pancreatic agent. | |
