Longikaurin ECAS# 77949-42-9 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
Cas No. | 77949-42-9 | SDF | Download SDF |
PubChem ID | 157135 | Appearance | Powder |
Formula | C22H30O6 | M.Wt | 390.5 |
Type of Compound | Diterpenoids | Storage | Desiccate at -20°C |
Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
SMILES | CC(=O)OC1CC2CC3(C1C45CCCC(C4C(C3(OC5)O)O)(C)C)C(=O)C2=C | ||
Standard InChIKey | VLCMAXYGZMNIMT-JPMZETMGSA-N | ||
Standard InChI | InChI=1S/C22H30O6/c1-11-13-8-14(28-12(2)23)15-20-7-5-6-19(3,4)16(20)18(25)22(26,27-10-20)21(15,9-13)17(11)24/h13-16,18,25-26H,1,5-10H2,2-4H3/t13-,14-,15+,16-,18+,20-,21+,22?/m1/s1 | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Description | 1. Longikaurin E induces apoptosis of pancreatic cancer cells via ROS generation to modulate the p38 and PI3K/AKT pathways and could be a promising anti-pancreatic agent. |
Targets | ROS | p38MAPK | PI3K | Akt | Caspase |
Longikaurin E Dilution Calculator
Longikaurin E Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 2.5608 mL | 12.8041 mL | 25.6082 mL | 51.2164 mL | 64.0205 mL |
5 mM | 0.5122 mL | 2.5608 mL | 5.1216 mL | 10.2433 mL | 12.8041 mL |
10 mM | 0.2561 mL | 1.2804 mL | 2.5608 mL | 5.1216 mL | 6.402 mL |
50 mM | 0.0512 mL | 0.2561 mL | 0.5122 mL | 1.0243 mL | 1.2804 mL |
100 mM | 0.0256 mL | 0.128 mL | 0.2561 mL | 0.5122 mL | 0.6402 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Dinaciclib (SCH727965)
Catalog No.:BCC3765
CAS No.:779353-01-4
- Doxazosin Mesylate
Catalog No.:BCC1257
CAS No.:77883-43-3
- Beta-Lipotropin (1-10), porcine
Catalog No.:BCC1009
CAS No.:77875-68-4
- Isopulegol
Catalog No.:BCN4974
CAS No.:7786-67-6
- Oglemilast
Catalog No.:BCC1817
CAS No.:778576-62-8
- (1R)-(+)-Alpha-Pinene
Catalog No.:BCC8275
CAS No.:7785-70-8
- Nelumol A
Catalog No.:BCN4749
CAS No.:77836-86-3
- GNF 5
Catalog No.:BCC3892
CAS No.:778277-15-9
- GNF 2
Catalog No.:BCC3891
CAS No.:778270-11-4
- Carasinol B
Catalog No.:BCN8226
CAS No.:777857-86-0
- Dehydrocrebanine
Catalog No.:BCN4328
CAS No.:77784-22-6
- Potassium phosphate monobasic
Catalog No.:BCC7583
CAS No.:7778-77-0
- Z-Glycinol
Catalog No.:BCC3095
CAS No.:77987-49-6
- Secologanin dimethyl acetal
Catalog No.:BCN4581
CAS No.:77988-07-9
- Mulberrofuran C
Catalog No.:BCN4032
CAS No.:77996-04-4
- Isophorone
Catalog No.:BCN8329
CAS No.:78-59-1
- Linalool
Catalog No.:BCN6339
CAS No.:78-70-6
- Zeylasterone
Catalog No.:BCN8057
CAS No.:78012-25-6
- 1,3-Diacetylvilasinin
Catalog No.:BCN4580
CAS No.:78012-28-9
- MMPX
Catalog No.:BCC6692
CAS No.:78033-08-6
- Fmoc-Lys(Fmoc)-OH
Catalog No.:BCC3521
CAS No.:78081-87-5
- (R)-(+)-8-Hydroxy-DPAT hydrobromide
Catalog No.:BCC6929
CAS No.:78095-19-9
- 2-Acetylfluorene
Catalog No.:BCC8516
CAS No.:781-73-7
- Aztreonam
Catalog No.:BCC2557
CAS No.:78110-38-0
Longikaurin E induces apoptosis of pancreatic cancer cells via modulation of the p38 and PI3K/AKT pathways by ROS.[Pubmed:25743573]
Naunyn Schmiedebergs Arch Pharmacol. 2015 Jun;388(6):623-34.
Pancreatic cancer is a devastating disease with a poor prognosis. It ranks as the fourth or fifth most common cancer in men and women and has the lowest 5-year survival rate. Therefore, there is an urgent need to develop novel therapeutic agents for pancreatic cancer. Longikaurin E (LE), which is derived from the traditional herbal medicine Rabdosia longituba, had been reported to have anti-proliferative and pro-apoptotic properties in several types of cancers. In this study, we investigated the cytotoxic properties of LE against pancreatic cancer cells and explored the mechanism behind the observed apoptosis. Pancreatic cancer cell lines cultured in the presence of LE exhibited dose- and time-dependent growth suppression by clone formation, methylthiazoltetrazolium assay, lactate dehydrogenase cytotoxicity assay, and fluorescence-activated cell sorting analysis, respectively. In addition, these culture conditions also induced the generation of cellular reactive oxygen species (ROS). In order to determine the mechanisms underlying LE-induced cytotoxicity, we used reverse transcription polymerase chain reaction and Western blot analysis in the pancreatic cancer cell line PANC1. The results showed that the expression of Bax was noticeably upregulated and the expression levels of Bcl-2, Bcl-XL, survivin, and c-Myc were significantly downregulated. We also observed increased p38 phosphorylation and decreased phosphorylation of the PI3K/AKT pathway. Interestingly, we also found that LE activated caspase-3. However, N-acetyl-L-cysteine, a kind of antioxidant, reversed all of these cellular activities. In conclusion, this study suggested that LE induced apoptosis of pancreatic cancer cells via ROS generation to modulate the p38 and PI3K/AKT pathways and could be a promising anti-pancreatic agent.