Zeylasterone

CAS# 78012-25-6

Zeylasterone

Catalog No. BCN8057----Order now to get a substantial discount!

Product Name & Size Price Stock
Zeylasterone: 5mg Please Inquire In Stock
Zeylasterone: 10mg Please Inquire In Stock
Zeylasterone: 20mg Please Inquire Please Inquire
Zeylasterone: 50mg Please Inquire Please Inquire
Zeylasterone: 100mg Please Inquire Please Inquire
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Quality Control of Zeylasterone

Number of papers citing our products

Chemical structure

Zeylasterone

3D structure

Chemical Properties of Zeylasterone

Cas No. 78012-25-6 SDF Download SDF
PubChem ID 13945472 Appearance Powder
Formula C30H38O7 M.Wt 510.62
Type of Compound Triterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (6aS,6bS,8aS,11R,12aR,14aR)-2,3-dihydroxy-11-methoxycarbonyl-6a,6b,8a,11,14a-pentamethyl-5-oxo-7,8,9,10,12,12a,13,14-octahydropicene-4-carboxylic acid
SMILES CC12CCC(CC1C3(CCC4(C5=CC(=C(C(=C5C(=O)C=C4C3(CC2)C)C(=O)O)O)O)C)C)(C)C(=O)OC
Standard InChIKey DXDSZUXZQIKMRQ-GMZGOHOASA-N
Standard InChI InChI=1S/C30H38O7/c1-26-7-8-27(2,25(36)37-6)15-20(26)30(5)12-10-28(3)16-13-18(32)23(33)22(24(34)35)21(16)17(31)14-19(28)29(30,4)11-9-26/h13-14,20,32-33H,7-12,15H2,1-6H3,(H,34,35)/t20-,26-,27-,28+,29-,30+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Zeylasterone

The herbs of Tripterygium wilfordii

Biological Activity of Zeylasterone

Description1. Zeylasterone shows bactericidal activity.

Zeylasterone Dilution Calculator

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Zeylasterone Molarity Calculator

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Preparing Stock Solutions of Zeylasterone

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.9584 mL 9.792 mL 19.584 mL 39.1681 mL 48.9601 mL
5 mM 0.3917 mL 1.9584 mL 3.9168 mL 7.8336 mL 9.792 mL
10 mM 0.1958 mL 0.9792 mL 1.9584 mL 3.9168 mL 4.896 mL
50 mM 0.0392 mL 0.1958 mL 0.3917 mL 0.7834 mL 0.9792 mL
100 mM 0.0196 mL 0.0979 mL 0.1958 mL 0.3917 mL 0.4896 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Zeylasterone

Antibacterial properties of zeylasterone, a triterpenoid isolated from Maytenus blepharodes, against Staphylococcus aureus.[Pubmed:20116223]

Microbiol Res. 2010 Oct 20;165(8):617-26.

The anti-staphylococcal properties of Zeylasterone and demethylZeylasterone, two 6-oxophenolic triterpenoids isolated from Maytenus blepharodes, were investigated. Zeylasterone was more active than demethylZeylasterone on Staphylococcus aureus cells, showing bactericidal activity at 30 mug/ml (6 x MIC) in less than three hours and bacteriostatic at lower concentrations. At the same cell density, a more drastic reduction in CFU count was obtained when the triterpenoid was incorporated into cultures growing actively. Zeylasterone at 3 x MIC added on S. aureus cultures showed an early inhibitory effect on incorporation of radiolabeled thymidine, uridina and N-acetyl-glucosamine, and later on leucine. It also caused cell membrane disruption in S. aureus, as shown by the inhibition of radiolabeled precursor uptake, rapid potassium leakage, inhibition of NADH oxidation, and formation of mesosome-like structures around the septa. The structural features of the molecule, the blockage of solute transport through the membrane and changes in its permeability, suggest that Zeylasterone acts mainly on cytoplasmic membrane.

Activity and mechanism of the action of zeylasterone against Bacillus subtilis.[Pubmed:18070038]

J Appl Microbiol. 2008 May;104(5):1266-74.

AIMS: To investigate the antimicrobial properties of 6-oxophenolic triterpenoids isolated from Maytenus blepharodes against different micro-organisms and the mode of action on Bacillus subtilis. METHODS AND RESULTS: The activity of Zeylasterone and demethylZeylasterone was evaluated by microdilution method. Zeylasterone showed a higher activity, being active against Gram-positive bacteria (minimum inhibitory concentration 3-20 microg ml(-1)) and Candida albicans (10 microg ml(-1)). Killing curves revealed a bacteriostatic effect on B. subtilis that was dependent on the growth phase and inoculum size. Zeylasterone caused cell membrane alterations in B. subtilis, as shown by potassium leakage and formation of mesosome-like structures. However, membrane disruption was not revealed by either LIVE/DEAD Baclight assay or measurement of intracellular constituent efflux. Zeylasterone showed an early effect on N-acetyl-glucosamine and uridine incorporation and later on that of thymidine and leucine. CONCLUSIONS: Diverse micro-organisms exhibit sensitivities towards compounds studied. The permeability changes in the cytoplasmic membrane and nonsimultaneous ceasing of macromolecular synthesis suggest that Zeylasterone could act on multiple targets on B. subtilis. SIGNIFICANCE AND IMPACT OF THE STUDY: The activity showed against B. subtilis as a model of spore-forming bacteria would provide valuable information for further studies in the development of 6-oxophenolic triterpenoids as antiseptic and disinfectant properties.

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