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Mulberrofuran C

CAS# 77996-04-4

Mulberrofuran C

Catalog No. BCN4032----Order now to get a substantial discount!

Product Name & Size Price Stock
Mulberrofuran C: 5mg $1098 In Stock
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Quality Control of Mulberrofuran C

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Chemical structure

Mulberrofuran C

3D structure

Chemical Properties of Mulberrofuran C

Cas No. 77996-04-4 SDF Download SDF
PubChem ID 157143 Appearance Powder
Formula C34H28O9 M.Wt 580.6
Type of Compound Phenols Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name [(1S,2R,6R)-2-[2,6-dihydroxy-4-(6-hydroxy-1-benzofuran-2-yl)phenyl]-6-(2,4-dihydroxyphenyl)-4-methylcyclohex-3-en-1-yl]-(2,4-dihydroxyphenyl)methanone
SMILES CC1=CC(C(C(C1)C2=C(C=C(C=C2)O)O)C(=O)C3=C(C=C(C=C3)O)O)C4=C(C=C(C=C4O)C5=CC6=C(O5)C=C(C=C6)O)O
Standard InChIKey WTGKDESIYCVAOP-UNTHUGQZSA-N
Standard InChI InChI=1S/C34H28O9/c1-16-8-24(22-6-4-19(35)13-26(22)38)32(34(42)23-7-5-20(36)14-27(23)39)25(9-16)33-28(40)10-18(11-29(33)41)30-12-17-2-3-21(37)15-31(17)43-30/h2-7,9-15,24-25,32,35-41H,8H2,1H3/t24-,25+,32-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Mulberrofuran C

The root bark of Morus alba L.

Biological Activity of Mulberrofuran C

Description1. Mulberrofuran C shows protective effects on t-BHP-induced oxidative stress with the EC50 value of 0.41 ± 0.48 uM ; it also shows protective effects on glutamate-induced cell death with the EC50 value of 16.50 ± 7.82 uM. 2. Mulberrofuran C has antiviral effects against herpes simplex virus type 1 and 2 (HSV-1 and HSV-2).
TargetsHSV

Mulberrofuran C Dilution Calculator

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Mulberrofuran C Molarity Calculator

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Preparing Stock Solutions of Mulberrofuran C

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.7224 mL 8.6118 mL 17.2236 mL 34.4471 mL 43.0589 mL
5 mM 0.3445 mL 1.7224 mL 3.4447 mL 6.8894 mL 8.6118 mL
10 mM 0.1722 mL 0.8612 mL 1.7224 mL 3.4447 mL 4.3059 mL
50 mM 0.0344 mL 0.1722 mL 0.3445 mL 0.6889 mL 0.8612 mL
100 mM 0.0172 mL 0.0861 mL 0.1722 mL 0.3445 mL 0.4306 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Mulberrofuran C

Anti-HSV Activity of Kuwanon X from Mulberry Leaves with Genes Expression Inhibitory and HSV-1 Induced NF-kappaB Deactivated Properties.[Pubmed:27725444]

Biol Pharm Bull. 2016;39(10):1667-1674.

Six stilbene derivatives isolated from Mulberry leaves including Kuwanon X, Mulberrofuran C, Mulberrofuran G, Moracin C, Moracin M 3'-O-b-glucopyranoside and Moracin M were found to have antiviral effects against herpes simplex virus type 1 and 2 (HSV-1 and HSV-2) at different potencies except for Mulberrofuran G. Kuwanon X exhibited the greatest activity against HSV-1 15577 and clinical strains and HSV-2 strain 333 with IC50 values of 2.2, 1.5 and 2.5 microg/mL, respectively. Further study revealed that Kuwanon X did not inactivate cell-free HSV-1 particles, but inhibited cellular adsorption and penetration of HSV-1 viral particles. Following viral penetration, Kuwanon X reduced the expression of HSV-1 IE and L genes, and decreased the synthesis of HSV-1 DNA. Furthermore, it was demonstrated that Kuwanon X inhibited the HSV-1-induced nuclear factor (NF)-kappaB activation through blocking the nuclear translocation and DNA binding of NF-kappaB. These results suggest that Kuwanon X exerts anti-HSV activity through multiple modes and could be a potential candidate for the therapy of HSV infection.

Isoprenylated flavonoids from the root bark of Morus alba and their hepatoprotective and neuroprotective activities.[Pubmed:25981820]

Arch Pharm Res. 2015 Nov;38(11):2066-75.

A new isoprenylated flavonoid, 2S-5,7,2',4'-tetrahydroxy-3',5'-di-(gamma,gamma-dimethylallyl)flavanone, sanggenol Q (1), along with seven known isoprenylated flavonoids, sanggenol A (2), sanggenol L (3), kuwanon T (4), cyclomorusin (5), sanggenon F (6), sanggenol O (7), and sanggenon N (8), three known Diels-Alder type adducts, sanggenon G (9), mulberrofuran G (10), and Mulberrofuran C (11), and a known benzofuran, moracin E (12), were isolated from the root bark of Morus alba using silica gel, ODS, and Sephadex LH-20 column chromatography. Chemical structures were determined based on spectroscopic data analyses including NMR, MS, CD, and IR. For the first time, compounds 1 and 7 were isolated from the root bark of M. alba. All compounds were evaluated for hepatoprotective activity on t-BHP-induced oxidative stress in HepG2 cells and neuroprotective activity on glutamate-induced cell death in HT22 cells. Compounds 1, 4, 8, 10, and 11 showed protective effects on t-BHP-induced oxidative stress with EC50 values of 6.94 +/- 0.38, 30.32 +/- 6.82, 23.45 +/- 4.72, 15.31 +/- 2.21, and 0.41 +/- 0.48 muM, respectively, and compounds 1, 2, 10, 11, and 12 showed protective effects on glutamate-induced cell death with EC50 values of 5.54 +/- 0.86, 34.03 +/- 7.71, 19.71 +/- 0.71, 16.50 +/- 7.82, and 1.02 +/- 0.13 muM, respectively.

Synthetic studies towards the mulberry Diels-Alder adducts: H-bond accelerated cycloadditions of chalcones.[Pubmed:22488146]

Org Biomol Chem. 2012 Aug 14;10(30):6010-21.

The methyl ether derivatives 2, 4 and 6 of the mulberry Diels-Alder adducts chalcomoracin (1) and Mulberrofuran C (3) and kuwanon J (5) respectively have been synthesized by a thermal [4 + 2]-cycloaddition reaction between a chalcone and dehydroprenyl diene. A H-bonded ortho OH substituent on the chalcone was found to be essential for Diels-Alder reactivity. Density functional theory calculations show that the OH group lowers the barrier for the Diels-Alder reaction by 2-3 kcal mol(-1) compared with OMe. The acceleration by the OH group is traced to two transition-state effects: a stronger diene-chalcone interaction and better planarity of the aryl-diene unit.

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