Secologanin dimethyl acetalCAS# 77988-07-9 |
Quality Control & MSDS
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Chemical structure
![Secologanin dimethyl acetal](/media/images/struct/BCN4581.png)
3D structure
Cas No. | 77988-07-9 | SDF | Download SDF |
PubChem ID | 157140 | Appearance | Powder |
Formula | C19H30O11 | M.Wt | 434.44 |
Type of Compound | Iridoids | Storage | Desiccate at -20°C |
Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
Chemical Name | methyl (2S,3R,4S)-4-(2,2-dimethoxyethyl)-3-ethenyl-2-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,4-dihydro-2H-pyran-5-carboxylate | ||
SMILES | COC(CC1C(C(OC=C1C(=O)OC)OC2C(C(C(C(O2)CO)O)O)O)C=C)OC | ||
Standard InChIKey | HUVIXLWRQSMCLN-PXRCHJMLSA-N | ||
Standard InChI | InChI=1S/C19H30O11/c1-5-9-10(6-13(25-2)26-3)11(17(24)27-4)8-28-18(9)30-19-16(23)15(22)14(21)12(7-20)29-19/h5,8-10,12-16,18-23H,1,6-7H2,2-4H3/t9-,10+,12-,14-,15+,16-,18+,19+/m1/s1 | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Description | 1. Secologanin dimethyl acetal induces significant neurite outgrowth. |
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Secologanin dimethyl acetal Dilution Calculator
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Secologanin dimethyl acetal Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 2.3018 mL | 11.5091 mL | 23.0181 mL | 46.0363 mL | 57.5453 mL |
5 mM | 0.4604 mL | 2.3018 mL | 4.6036 mL | 9.2073 mL | 11.5091 mL |
10 mM | 0.2302 mL | 1.1509 mL | 2.3018 mL | 4.6036 mL | 5.7545 mL |
50 mM | 0.046 mL | 0.2302 mL | 0.4604 mL | 0.9207 mL | 1.1509 mL |
100 mM | 0.023 mL | 0.1151 mL | 0.2302 mL | 0.4604 mL | 0.5755 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
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New physiological function of secoiridoids: neuritogenic activity in PC12h cells.[Pubmed:20652643]
J Nat Med. 2011 Jan;65(1):186-90.
Previously, we have reported that geniposide isolated from an extract of Gardenia fructus has neuritogenic activity in PC12h cells, a subclone of rat pheochromocytoma cells. Furthermore, we have indicated that several geniposide-related iridoid compounds also had similar potent neuritogenic activity. In this study, we have examined the effects of various secoiridoid compounds [K-1, sweroside; K-2, swertiamarin; K-3, gentiopicroside; K-4, 6'-O-beta-D: -glucopyranosylsweroside; K-5, 6'-O-beta-D: -glucopyranosylgentiopicroside; K-6, 6'-O-beta-D: -glucopyranosylswertiamarin; K-7, 5'-O-beta-D: -glucopyranosylamarogentin; K-8, 5'-O-beta-D: -glucopyranosylamaroswertin; H-1, n-butyl vogeloside; H-2, n-butyl epivogeloside; H-3, (7S)-secologanin butyl methyl acetal; H-4, (7R)-secologanin butyl methyl acetal; H-5, Secologanin dimethyl acetal] isolated from various medicinal herbs. The secoiridoids H-1, H-2, H-3, H-4, and H-5 induced significant neurite outgrowth. Among these H-series compounds, H-2 was the most potent neuritogenic compound. Among the K-series compounds, K-1, K-2, K-3, and K-8 showed the most potent activity. These results suggest that secoiridoids have neuritogenic activity in PC12h cells and that these secoiridoid compounds are promising starting compounds for the development of neurotrophic factor-like and iridoid compounds.