Products with Pro-apoptotic bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN4333 | 9-Oxo-10,11-dehydroageraphorone |
| 1. 9-Oxo-10,11-dehydroageraphorone has acaricidal activity. 2. 9-Oxo-10,11-dehydroageraphorone induces hepatotoxicity and cholestasis in rats. 3. 9-Oxo-10,11-dehydroageraphorone effectively inhibits the proliferation of HeLa cells by arresting the cell cycle transition from S to G2/M phase. | |
| BCN4343 | Schinifoline |
| Schinifoline has cytotoxic activity, it also shows in vitro radiosensitising, cell cycle and apoptotic-inducing effects. | |
| BCN4387 | Rocaglamide |
| 1. Rocaglamide induces apoptosis through the intrinsic death pathway in various human leukemia cell lines and in acute lymphoblastic leukemia, chronic myeloid leukemia and acute myeloid leukemia cells freshly isolated from patients. 2. Rocaglamides are potent natural anticancer products that inhibit proliferation of various cancer cells at nanomolar concentrations, it prevents tumor growth and sensitize resistant cancer cells to apoptosis by blocking the MEK-ERK-eIF4 pathway. 3. Rocaglamides can suppress the PMA-induced expression of NF-kappaB target genes and sensitize leukemic T cells to apoptosis induced by TNFalpha, cisplatin, and gamma-irradiation, suggests that rocaglamide derivatives could serve as lead structures in the development of anti-inflammatory and tumoricidal drugs. 4. Rocaglamide and a XIAP inhibitor cooperatively sensitize TRAIL-mediated apoptosis in Hodgkin's lymphomas. | |
| BCN4458 | Tenacigenoside A |
| 1. Tenacigenoside A and 11α-O-benzoyl-12β-O-acetyltenacigenin B (TGTB) can significantly increase tumor cell apoptosis on lymphoma bearing mice primarily through down-regulation of BCL2 and BCL-XL, and up-regulation of BID. | |
| BCN4638 | Isodeoxyelephantopin |
| 1. Isodeoxyelephantopin exerts antitumor effects on several cancer cells by inducing apoptosis , cell cycle arrest , and inhibiting proliferation . 2. Isodeoxyelephantopin enhances apoptosis and inhibit invasion and osteoclastogenesis by inhibiting NF-kappaB activation and NF-kappaB-regulated gene expression. | |
