Products with Pro-apoptotic bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN3010 | Furanodienone |
| Furanodienone inhibits EGFR/HER2 signaling pathway in BT474 and SKBR3 cells, the effect is specifically dependent on the expression of HER2 but not EGFR; it also has effects on MCF-7 cells are mediated, at least in part, by inhibiting ERα signaling. | |
| BCN3013 | Vicenin -2 |
| Vicenin -2 has hepatoprotective, anti-cancer, antioxidant and anti-inflammatory activities, and DTL co-administration is more effective than either of the single agents in androgen-independent prostate cancer. Vicenin -2 might be a useful lead for the development of multiple target-oriented therapeutic modalities for the treatment of diabetes and diabetes-associated complications. Vicenin -2 could act as a UV light barrier to protect the plants. | |
| BCN3020 | Delphinidin-3-O-glucoside chloride |
| 1. Delphinidin-3-O-glucoside chloride has antioxidant activity. | |
| BCN3075 | Isomorellinol |
| 1. Isomorellinol induces apoptosis in cholangiocarcinoma (CCA)cells which is mediated through a mitochondria-dependent signaling pathway. | |
| BCN3085 | Wilfortrine |
| Wilfortrine can induce liver cancer cell HepG2 apoptosis, but with no effect on the cell cycle, mainly by promoting Bax expression and inhibiting anti-apoptotic protein Bcl-2 expression. The combined treatment using wilfortrine and paclitaxel can inhibit proliferation and invasion of liver cancer cells via down-regulating Bcl-2 and up-regulating Bax, with better efficacy than single use of either drug. Wilfortrine and euonine (40.80 mg/(kg.d) x 4d ip) show marked depressant effects on humoral mediated immunity using the hemolysin reaction as indices. | |
