Products with Pro-apoptotic bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN6657 | Sprengerinin C |
| 1. Sprengerinin C can strongly suppress tumor angiogenesis in human umbilical vein endothelial cells, it blocks vascular endothelial growth factor receptor 2-dependent phosphoinositide 3-kinase/Akt/mTOR/matrix metalloproteinase and p38 MAPK/matrix metalloproteinase pathways,two major pathways for tumor angiogenesis; sprengerinin C also can induce HepG-2/BEL7402 cell apoptosis by activating NADPH oxidase/reactive oxygen species-dependent caspase apoptosis pathway and suppress HepG-2/BEL7402 cell growth through p53-mediated G2/M-phase arrest, suggests that sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis. | |
| BCN6696 | Delta-Tocotrienol |
| 1. Delta-tocotrienol displays significant radioprotective effects, it protects mouse and human hematopoietic progenitors from gamma-irradiation through extracellular signal-regulated kinase/mammalian target of rapamycin signaling. 2. Delta-tocotrienol is a potential angiogenic inhibitor, it (2.5-5 microM) can significantly suppress human colorectal adenocarcinoma cells (DLD-1-CM) -induced tube formation, migration, and adhesion on human umbilical vein endothelial cells. 3.Delta-tocotrienol is a nontoxic activator of mir-34a which can inhibit nonsmall cell lung cancer cells (NSCLC) cell proliferation, induce apoptosis and inhibit invasion, and thus offering a potential starting point for the design of novel anticancer agents. 4.Grape seed polyphenol and delta-tocotrienol may have benefits in reducing non-alcoholic steatohepatitis (NASH, the second phase in liver disease). | |
| BCN6774 | Uncarinic acid E |
| 1. Uncarinic acid E shows moderate cytotoxicity against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and Bt549) (IC50 < 20.0 uM). 2. Uncarinic acid E induces apoptosis in HepG2 cells via accumulation of p53, alters the Bax/Bcl-2 ratio, and activates caspases, resulting in cytochrome c release from the mitochondria. 3. Uncarinic acid E shows dose-dependent inhibitory activities against PLCgamma1 in vitro with the IC(50) value of 9.5-44.6 microM and inhibits the proliferation of human cancer cells with the IC(50) value of 0.5-6.5 microg/mL. 4. A mixture of uncarinic acid E and 27-O-p-(E)-coumaroyloxyursolic acid exhibits antiplasmodial activity, with the IC50 value of 2.9 microg/ml. | |
| BCN6791 | Cytosporone B |
| Cytosporone B is a naturally occurring agonist for Nur77, it also is a Salmonella pathogenicity island 1 (SPI-1)-inhibitor, it may have potential in drug development against antibiotic-resistant Salmonella. Cytosporone B can elevate blood glucose levels in fasting C57 mice, an effect that is accompanied by induction of multiple genes involved in gluconeogenesis. Cytosporone B can inhibit transforming growth factor-b (TGF-β)-induced contraction of human corneal fibroblasts (HCFs), likely as a result of its attenuation of the up-regulation of α-SMA expression. | |
| BCN6794 | Harringtonine |
| Harringtonine , an anticancer drug with high chemotherapeutic efficiency to human chronic granulocytic/myelomonocytic leukemia, has been reported to rapidly induce apoptosis in HL-60 cells in a wide scope/range of dosage by investigators from our lab and others. Harringtonine exerts its antiviral effects by inhibiting Chikungunya virus (CHIKV) viral protein synthesis. | |
