Products with Pro-apoptotic bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN3447 | Kurarinol |
| 1. Kurarinol is a potent inhibitor of sortase A, with an IC50 value of 107.7 ± 6.6 μM. 2. Kurarinol has extremely strong tyrosinase inhibitory activity, exerts varying degrees of inhibition on tyrosinase-dependent melanin biosynthesis, is a candidate as skin-whitening agents. | |
| BCN3473 | Momordin II |
| 1. Highly purified Momordin II inhibits cell-free protein synthesis, releases adenine from rat liver ribosomes and from DNA, and has no RNase activity. | |
| BCN3548 | Vallesiachotamine |
| 1. Vallesiachotamine exhibits important cytotoxicity toward human melanoma cells by apoptosis and necrosis. | |
| BCN3639 | Toddaculine |
| 1. Toddaculine can not only inhibit the differentiation of osteoclasts via activation of the NF-κB, ERK 1/2, and p38 MAPK signaling pathways, but can induce differentiation and mineralization of osteoblasts by regulating differentiation factors. 2. Toddaculine may be beneficial for the prevention and treatment of osteoporosis. 3. Toddaculine displays a dual effect as a cell differentiating agent and apoptosis inducer in U-937 cells, suggesting it may serve as a pharmacological prototype for the development of novel anti-leukemic agents. | |
| BCN3673 | 7-Hydroxyflavone |
| 7-Hydroxyflavone is a potent inhibitor of CYP1A1 with a Ki value of 0.015 μM and exhibits 6-fold greater selectivity for CYP1A1 over CYP1A2. It also has excellent antioxidant, anti-inflammatory, and anti-proliferation properties, it may serve as potential protective agents in the treatment of patients with chronic EV71 infection.7-Hydroxyflavone can protect renal cells from NIC-associated cytotoxicity via the ERK/Nrf2/HO-1 pathway; it also can inhibit LPS-induced inflammation via attenuating the production of NO, PGE2 , TNF-α and IL-6. | |
