Products with Pro-apoptotic bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN6457 | Lanatoside C |
| 1. Lanatoside C, a cardiac glycoside, is an anti-arrhythmic agent. 2. Lanatoside C acts through protein kinase Cδ to cause apoptosis of human hepatocellular carcinoma cells. 3. Lanatoside C can effectively inhibit all four serotypes of dengue virus, flavivirus Kunjin, alphavirus Chikungunya and Sindbis virus as well as the human enterovirus 71, suggest that lanatoside C possesses broad spectrum antiviral activity against several groups of positive-sense RNA viruses. | |
| BCN6505 | Juglanin |
| Juglanin has anti-tumor, antioxidant,and hepatoprotective activities. Juglanin shows protective effects on fructose-induced hepatitis by inhibiting inflammation and apoptosis through TLR4 and JAK2/STAT3 signaling pathways in fructose-fed rats. Juglanin can lead to G2/M phase arrest, induce apoptosis as well as autophagy through the ROS/JNK signaling pathway in human breast cancer cells | |
| BCN6526 | Continentalic acid |
| 1. Continentalic acid and kaurenoic acid are quality control markers in Aralia continentalis. 2. Continentalic acid shows moderate cytotoxicity against A-549 (lung), THP-1 (leukemia) and MCF-7 (breast) cell lines. 3. Continentalic acid exerts significant anti-inflammatory activity. 4. Continentalic acid can efficiently induces apoptosis and is a good candidate for further evaluation as an effective chemotherapeutic agent. 5. Continentalic acid has minimum inhibitory concentrations (MICs) of approximately 8-16 microg/mL against S. aureus, including the MSSA and MRSA standard strains. | |
| BCN6579 | Xanthoxyletin |
| 1. Xanthoxyletin shows cytotoxic activity, it can inhibit the incorporation of tritiated thymidine into human leukaemia (HL-60) cells. 2. Xanthoxyletin induces S phase arrest and apoptosis in human gastric adenocarcinoma SGC-7901 cells, the effects are associated with the DNA damage, apoptosis through mitochondrial dysfunction, and cell cycle arrest at S phase in a dose-dependent manner, it also can increase the production of reactive oxygen species, suggest that xanthoxyletin may be promising anticancer agent. 3. Xanthoxyletin shows anti-inflammatory activities, it shows an inhibitory effect on iNOS protein expression at 10 microM, it also can inhibit the synthesis of nitric oxide and the protein expression of tumor necrosis factor-alpha and cyclooxygenase-2 . 4. Xanthoxyletin shows potent antibacterial, fungicidal, and algicidal properties. | |
| BCN6607 | ent-16alpha,17-Dihydroxyatisan-3-one |
| 1. ent-16alpha,17-Dihydroxyatisan-3-one and ent-16alpha,17-dihydroxykauran-3-one have apoptosis induction activities on L5178 human MDR1 gene-transfected mouse lymphoma cells. | |
