Hot Natural Products & Bioactive Compounds

1. Santalol has good antibacterial, anti-oxidation and anti-tumor activities.
2. α-Santalol is a potent antimitotic agent induced by interference with microtubule assembly.
3. α-Santalol shows a significant antifungal effect against a dermatophytic fungus, Trichophyton rubrum.

Niga-ichigoside F1(NI) has anti-inflammatory, gastroprotective ,antinociceptive, and cytotoxic effects. NI showed an inhibition zone on β-glucosidase and anti-acetylcholinesterase assays. The dietary NI could prevent HFD-induced hepatic steatosis, possibly via interacting with HFD to activate Nrf2 nuclear translocation to maintain a redox status, thus regulating lipid metabolism genes expressions.

1. Steviol, a natural sweetener, it inhibits proliferation of the gastrointestinal cancer cells intensively.
2. Steviol can induce a significant increase in CYP3A29 expression.
3. Steviol inhibits the proliferation of the human osteosarcoma U2OS cell line in a dose- and time-dependent manner.
4. Steviol can treat polycystic kidney disease, it slowed cyst growth, in part, by reducing AQP2 transcription, promoted proteasome, and lysosome-mediated AQP2 degradation.

Dehydroandrographolide succinate can alleviate oxidative stress in LPS-induced acute lung injury possibly by inactivating iNOS. It combined with ribavirin treatedchildren with hand-foodand mouth disease,the duration of fever was shorter,rashes on hands and feet more quickyly.

1. Karanjin possesses gastroprotective property.
2. Karanjin possesses significant antioxidant activity.
3. Karanjin has larvicidal activity toward C. pipiens pallens larvae and A. aegypti larvae.
4. Karanjin plays anti-inflammatory role in experimental arthritis model as well as on macrophage signalling.
5. Karanjin is a potent Volume-regulated anion channels(VRACs) current inhibitor, the VRAC inhibition might be responsible for its anti-angiogenic effects.
6. Karanjin has the potential to cure colitis induced by intracolonic administration of 2,4,6-trinitrobenzenesulfonic acid (TNBS).
7. Karanjin can significantly reverse the amnesia induced by diazepam and improve learning and memory of mice in dose and time dependent manner.
8. Karanjin can induce cancer cell death through cell cycle arrest and enhance apoptosis, it may be effective clinically for cancer pharmacotherapy.
9. Karanjin possesses significant antihyperglycemic activity in Streptozotocin-induced diabetic rats and type 2 diabetic db/db mice and protein tyrosine phosphatase-1B may be the possible target for their activity.

Notoginsenoside S may have hepatoprotective effects.

1. Nervonic acid can inhibit DNA polymerase beta and HIV-1 reverse transcriptase.
2. Nervonic Acid improves learning memory ability in normal mice and mice with experimental memory impairment.

1. Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β-catenin in breast cancer cells.
2. Gigantol may be developed as a promising neuroprotective agent for successful MSC transplantation in ischemic diseases, it shows protective effect against hydrogen peroxide-induced apoptosis in rat bone marrow mesenchymal stem cells through the PI3K/Akt pathway.
3. Gigantol inhibits aldose reductase gene to exert its anti-cataract activity.
4. Gigantol induces growth inhibition and apoptosis of HepG2 cells via the PI3K/Akt/NF-κB signaling pathway.
5. Gigantol shows α-glucosidase inhibitory activity.