Hot Natural Products & Bioactive Compounds

1. Octyl Gallate is an antioxidant approved by the US Food and Drug Administration (FDA) as a food additive.
2. Octyl Gallate has antimetastatic activity.
3. Octyl Gallate shows antimicrobial activity against H. pylori, with a minimum inhibitory concentration (MIC) value of 125 ug/mL.
4. Combination therapy with octyl gallate and ferulic acid improves cognition and neurodegeneration in a transgenic mouse model of Alzheimer's disease.
5. Octyl Gallate is a potential anticancer agent, it exhibited decreased MCF-7 & MDA-MB-231 survival and induced apoptosis, with IC50 value of 40 uM.
6. Octyl gallate has antiviral activity, it shows an inhibitory effect on the growth of herpes simplex virus type 1 (HSV-1) in HEp-2 or Vero cells.
7. Octyl gallate shows antifungal activity against Saccharomyces cerevisiae ATCC7754 and Zygosaccharomyces bailii ATCC 60483.

Voacanginine may have rhythmic effects.

1. Aloenin and aloe-emodin are active principles for inhibition of c-ADH and c-ALDH activities in vitro.

1. Glaucocalyxin B alleviates lipopolysaccharide-induced Parkinson's disease by inhibiting TLR/NF-κB and activating Nrf2/HO-1 Pathway.
2. Glaucocalyxin B is a potent NF-κB inhibitor for Alzheimer's disease treatment.
3. Glaucocalyxin B shows sensitization of gastric cancer cells to alkylating agents via cell cycle arrest and enhances cell death.
4. Glaucocalyxin B induces apoptosis and autophagy in human cervical cancer cells.
5. Glaucocalyxin B has anti-inflammatory effects, it exhibits neuroprotective effect by preventing over-activated microglia induced neurotoxicity in a microglia/neuron co-culture model.

1. Lotusine has antihypertension and antibacterial activities.

The biological screening of cycleanine and the root bark alkaloidal extract revealed potent antibacterial, antifungal, antiplasmodial, and cytotoxic activities. Cycleanine, like its isomer – tetrandrine isolated from T. subcordata, could be a potential new anti-ovarian cancer agent acting through the apoptosis pathway. It also shows antiplasmodial activities against Plasmodium falciparum 3D7 with IC50 values of 0.08 µM.Cycleanine may have anti-inflammatory activity. Cycleanine markedly inhibited Na(+),K(+)-ATPase activity with an IC(50) value of 6.2 x 10(-4)M. It slightly inhibited Mg(2+)-ATPase, H(+)-ATPase, and Ca(2+)-ATPase, it might interact with the enzyme in Na.E(1)-P form and prevents the reaction step from Na.E(1)-P to E(2)-P.

Mogrol has exhibited anti-cancer activities, it suppressed leukemia cell growth via inhibition of the ERK1/2 and STAT3 pathways, in particular, through the suppression of p-ERK1/2 and p-STAT3.
Mogrol significantly improved LPS-induced memory impairment in mice. It also suppressed adipogenesis by reducing CREB activation in the initial stage of cell differentiation and by activating AMPK signaling in both the early and late stages of this process.

1. Rubitecan is a novel oral inhibitor of topoisomerase I in the camptothecin class.
2. Rubitecan shows antitumour activity in patients with refractory pancreatic cancer who have failed prior treatments.