Hot Natural Products & Bioactive Compounds

1. Lindleyin is a novel phytoestrogen and might trigger many of the biological responses evoked by the physiological estrogens.

Peripheral decarboxylase inhibitor, used in combination with levodopa for treatment of Parkinsonism.

1. Corynoxine B, a natural autophagy inducer, restores the deficient cytosolic translocation of HMGB1 and autophagy in cells overexpressing SNCA, which may be attributed to its ability to block SNCA-HMGB1 interaction.
2. Corynoxine B exhibits prolongation of the thiopental-induced hypnosis on oral administration in mice.

Flavokawain C is a melanogenesis inhibitor, it inhibited melanogenesis with IC50 values of 6.9 uM. Flavokawain C has anti-tumor activity, it inhibited cell cycle and promoted apoptosis, associated with endoplasmic reticulum stress and regulation of MAPKs and Akt signaling pathways in HCT 116 human colon carcinoma cells.Flavokawain B and flavokawain C are melanogenesis inhibitors, they inhibit melanogenesis with IC50 values of 7.7uM and 6.9 uM, respectively. Flavokawain C inhibits cell cycle and promotes apoptosis, associated with endoplasmic reticulum stress and regulation of MAPKs and Akt signaling pathways in HCT 116 human colon carcinoma cells.

L-Fucitol inhibited the galactitol-positive strains of Escherichia coli K12.

5-Methyl-7-methoxyisoflavone is used by bodybuilders for its ergogenic properties.

1. Aloperine has antitumor effects , it can suppress the tumor growth and promote cell apoptosis and cell cycle arrest in PCa cells.
2. Aloperine protects mice against bleomycin-induced pulmonary fibrosis by attenuating fibroblast proliferation and differentiation.
3. Aloperine exhibits neuroprotective effects against oxidative stress in vitro, it can ameliorate oxidative damage against early brain injury following subarachnoid hemorrhage , most likely via the Nrf2-ARE survival pathway.
4. Aloperine attenuates hydrogen peroxide-induced injury via anti-apoptotic activity and suppression of the nuclear factor-κB signaling pathway.
5. Aloperine exerts significant inhibitive effects on acute inflammation and Type III and IV hypersensitivity caused by a variety of inflammatory agents.

1. Rhodiosin exhibits antioxidant activity.
2. Rhodiosin exhibits potent, dose-dependent inhibitory effects on acetylcholinesterase (AChE).
3. Rhodiosin can inhibit cytochrome P450 2D6 non-competitively with the IC50 value of 0.761 microM.
4. Rhodiosin has hepatoprotective effects, it shows a protective effect on D-galactosamine-induced cytotoxicity in primary cultured mouse hepatocytes.
5. Rhodiosin shows noncompetitive inhibition against Flavobacterium prolyl endopeptidase, with an IC50 of 41 microM, the enzyme that plays a role in the metabolism of proline-containing neuropeptidase which is recognized to be involved in learning and memory.
6. Rhodiosin shows the inhibitory activity of lipase in isolated mouse plasma in vitro with the IC50 value of 0.133 mM, it can significantly suppress the elevation of the postprandial blood triglyceride level, suggests that it could used as the treatment of lifestyle-related diseases such as hyperlipidemia and exogeneous obesity and as health foods.