Rhodiosin; Herbacetin-7-O-glucorhamnosideCAS# 86831-54-1 |
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| Cas No. | 86831-54-1 | SDF | Download SDF |
| PubChem ID | 76959646 | Appearance | Yellow-orange powder |
| Formula | C27H30O16 | M.Wt | 610.518 |
| Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
| Synonyms | Herbacetin 7-glucosylrhamnoside; 3,4',5,7,8-Pentahydroxyflavone 7-glucosylrhamnoside | ||
| Solubility | Soluble in methan | ||
| Chemical Name | 7-[(2S,3R,4R,5S,6S)-3,5-dihydroxy-6-methyl-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-3,5,8-trihydroxy-2-(4-hydroxyphenyl)chromen-4-one | ||
| SMILES | CC1C(C(C(C(O1)OC2=C(C3=C(C(=C2)O)C(=O)C(=C(O3)C4=CC=C(C=C4)O)O)O)O)OC5C(C(C(C(O5)CO)O)O)O)O | ||
| Standard InChIKey | WXBBQBYCUTXTJQ-ULMXTSOFSA-N | ||
| Standard InChI | InChI=1S/C27H30O16/c1-8-15(31)25(43-26-21(37)19(35)16(32)13(7-28)41-26)22(38)27(39-8)40-12-6-11(30)14-18(34)20(36)23(42-24(14)17(12)33)9-2-4-10(29)5-3-9/h2-6,8,13,15-16,19,21-22,25-33,35-38H,7H2,1H3/t8-,13+,15-,16+,19-,21+,22+,25+,26-,27-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The herbs of Rhodiola rosea L.
| Description | 1. Rhodiosin exhibits antioxidant activity. 2. Rhodiosin exhibits potent, dose-dependent inhibitory effects on acetylcholinesterase (AChE). 3. Rhodiosin can inhibit cytochrome P450 2D6 non-competitively with the IC50 value of 0.761 microM. 4. Rhodiosin has hepatoprotective effects, it shows a protective effect on D-galactosamine-induced cytotoxicity in primary cultured mouse hepatocytes. 5. Rhodiosin shows noncompetitive inhibition against Flavobacterium prolyl endopeptidase, with an IC50 of 41 microM, the enzyme that plays a role in the metabolism of proline-containing neuropeptidase which is recognized to be involved in learning and memory. 6. Rhodiosin shows the inhibitory activity of lipase in isolated mouse plasma in vitro with the IC50 value of 0.133 mM, it can significantly suppress the elevation of the postprandial blood triglyceride level, suggests that it could used as the treatment of lifestyle-related diseases such as hyperlipidemia and exogeneous obesity and as health foods. |
| Targets | AChR | P450 (e.g. CYP17) | Immunology & Inflammation related |
Rhodiosin; Herbacetin-7-O-glucorhamnoside Dilution Calculator
Rhodiosin; Herbacetin-7-O-glucorhamnoside Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.638 mL | 8.1898 mL | 16.3795 mL | 32.7591 mL | 40.9488 mL |
| 5 mM | 0.3276 mL | 1.638 mL | 3.2759 mL | 6.5518 mL | 8.1898 mL |
| 10 mM | 0.1638 mL | 0.819 mL | 1.638 mL | 3.2759 mL | 4.0949 mL |
| 50 mM | 0.0328 mL | 0.1638 mL | 0.3276 mL | 0.6552 mL | 0.819 mL |
| 100 mM | 0.0164 mL | 0.0819 mL | 0.1638 mL | 0.3276 mL | 0.4095 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Rhodiosin, isolated from the root of Rhodiola crenulata, is a specific non-competitive cytochrome P450 2D6 inhibitor with an IC50 of 0.420 μM and a Ki of 0.535 μM. Rhodiosin exhibits potent, dose-dependent inhibitory effects on acetylcholinesterase (AChE) with IC50 ranged from 57.50 to 2.43 μg/mL. Rhodiosin exhibits potent DPPH free radical scavenging activities, with an IC50 of 27.77 μM.
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