Hot Natural Products & Bioactive Compounds

1. Periplocymarin, a cardiac glycoside, has potential anti-cancer activity.
2. Octreotide-conjugated periplocymarin demonstrates tumor selectivity and may be useful as a targeting agent to improve the safety profile of cardiac glycosides for cancer therapy.

1. Dipotassium glycyrrhizinate is an anionic surfactant having anti-allergic and anti-inflammatory activities.

Armepavine exerts both in vitro and in vivo antifibrotic effects in rats, with inhibition of NF-κB, JunD and C/EBPß pathways. It also shows cytotoxic activity.

1. Irisolidone is a potent volume-regulated anion channel (VRAC) current inhibitor, it exhibits high efficacy for VRAC blockade with IC50s of 5-13 uM.
2. Irisolidone possesses high α-amylase inhibitory activity.
3. Irisolidone may attenuate ethanol-induced gastritis by inhibiting the infiltration of immune cells, particularly neutrophils, through the regulation of CXCL-4 or IL-8 secretion.
4. Irisolidone has anti-inflammatory activity, it may inhibit inflammatory reactions via NF-κB pathway.
5. Irisolidone shows inhibitory activity on nitric oxide production from lipopolysaccharide-activated primary rat microglia.
6. Irisolidone shows antiproliferative activity against amelanotic melanoma cells.
7. Irisolidone shows anti-platelet aggregation effects.
8. Irisolidone has potent hepatoprotective activity.
9. Irisolidone shows potent inhibitory activity against Helicobacter pylori.

Hesperetin-7-methyl ether is a natural prooduct from Citrus maxima.

Physcion 1-O-beta-D-glucoside is a tumor cell growth inhibitor.

1. Emodin 1-O-beta-D-glucoside has neuroprotective and uncoupling activities, and that it may be the a new uncoupler of nNOS-PSD-95.
2. Emodin 1-O-beta-D-glucoside shows inhibitory effects on various tumor cells proliferation.

1. Saikosaponin B4 can selectively inhibit ACTH-induced lipolysis.