Hot Natural Products & Bioactive Compounds

1. Ungeremine is a potential biofungicide against Penicillium roqueforti and Aspergillus niger.
2. Ungeremine have strong antibacterial activity against Flavobacterium columnare .
3. Ungeremine effectively targets mammalian as well as bacterial type I and type II topoisomerases.
4. Ungeremine shows strong acetylcholinesterase inhibitory activity(IC(50) value of 0.35 microM).
5. Ungeremine has antiprotozoal activity, it shows good activity in in vitro assays against Trypanosoma brucei rhodesiense, T. cruzi.

Protostemotinine is a natural product from Stemona japonica.

Cell-permeable inhibitor of protein kinase C (IC50 = 660 nM); competitive with respect to the phosphate acceptor and non-competitive with respect to ATP. Has a wide range of biological activities, including antiplatelet, anti-inflammatory, antibacterial and antitumor effects. Activates MAPK pathways, independent of PKC inhibition. Inhibits binding of BclXL to Bak (IC50 = 1.5 μM) or Bad proteins and stimulates apoptosis.

Xanthoangelol F showed strong PTP1B inhibitory effect with the IC50 values of 1.67 μg/mL. It inhibited phenylephrine-induced vasoconstriction through endothelium-dependent production of EDRF/NO and/or through the reduction of the [Ca2+]i elevation induced by phenylephrine.

1. Salviaflaside has antioxidant activity.

1. Neodiosmin has poor aqueous solubility but exerts a good debittering effect and is a strong antioxidant with potential applications in foods, beverages, and pharmaceutical preparations.

Osthenol shows antitumor-promoting activity, it also has antifungal and antibacterial activities.Osthenol potently and selectively inhibited recombinant human monoamine oxidase-A (hMAO-A) with an IC50 value of 0.74 µM; it exhibited a highly potent inhibitory activity on 5alpha-reductase type I in LNCaP cells with an IC50 value of 0.1 microg/ml; it also exhibited inhibitory activity on COX-1 with the IC50 value of 64.3 microM.

1. Anisodamine, an anticholinergic drug, has antishock effect, which is intimately linked to alpha7nAChR-dependent anti-inflammatory pathway.
2. Anisodamine, a vasoactive drug, can abate endogenous endotoxaemia subsequent to splanchnic vasoconstriction due to hypovolaemia.
3. Anisodamine causes the changes of structure and function in the transmembrane domain of the Ca(2+)-ATPase from sarcoplasmic reticulum.
4. Anisodamine demonstrates a direct cardiac depressive action at the myocyte level, which may be related to, at least in part, NO production and cholinoceptor antagonism.
5. Anisodamine inhibits shiga toxin type 2-mediated tumor necrosis factor-alpha production in vitro and in vivo.
6. Anisodamine alleviates inflammatory damage by significantly reducing the expressions of VEGF and ICAM-1, and shows significant protective effects in an animal model of infusion phlebitis.
7. Anisodamine protects the heart from ischemia/reperfusion (I/R) injury induced by cardiac arrest (CA) and resuscitation.