Hot Natural Products & Bioactive Compounds

1. Micheliolide has potential as a candidate drug for the treatment of diabetic nephropathy, it can effectively attenuate the high glucose-stimulated activation of NF-κB, the degradation of IκBα, and the expression of MCP-1, TGF-β1 and FN in rat mesangial cells (MCs).
2. Micheliolide ameliorates liver steatosis by upregulating PPAR-γ expression, thereby inhibiting NF-κB-mediated inflammation and activating AMPK/mTOR-dependent autophagy.
3. Micheliolide may serve as a neuroprotective agent in neuroinflammation-related neurodegenerative disorders. it can suppress LPS-induced neuroinflammatory responses.
4. Micheliolide plays anti-inflammatory and immunomodulatory roles in Mycobacterium tuberculosis-induced immune response by inhibiting NF-κB and NLRP3 inflammasome activation.
5. Micheliolide exerts its antineoplastic effects via inhibition of NF-κB expression and activity, and by generating intracellular reactive oxygen species (ROS).

1. Dihydroseselin type of pyranocoumarin possessing a 4'-isovaleryl group is important to suksdorfin's enhanced anti-HIV activity.

1. Arjunglucoside I has anti-inflammatory activity, it exhibits significant activity against carrageenan-induced paw edema in rat.
2. Arjunglucoside I shows antiproliferative activity against the A2780 human ovarian cancer cell line with an IC(50) value of 1.2 microM.

1. Poricoic acid B shows potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).
2. Poricoic acid B shows inhibitory activity against TPA-induced ear inflammatory oedema.

Tectoruside is a natural product from Iris tectorum.

1. Kakkalide is a potent lactate dehydrogenase (LDH) inhibitor.
2. Kakkalide attenuates ethanol-induced gastric injury in mice by inhibiting the infiltration of neutrophils.
3. Kakkalide can inhibit ROS-associated inflammation and ameliorated insulin-resistant endothelial dysfunction by beneficial effects on IRS-1 function.
4. Kakkalide has anti-inflammatory effects, it ameliorates carrageenan-induced inflammation in mice by inhibiting NF-κB pathway.
5. Kakkalide shows protective effects on ethanol-induced lethality and hepatic injury are dependent on its biotransformation by human intestinal microflora.

1. Obovatol has antioxidant, neuroprotective, antiinflammatory, antithrombotic and antitumour effects.
2. Obovatol is a potent NF-κB inhibitors for Alzheimer's disease treatment.
3. Obovatol shows inhibitory effect on the Salmonella type III secretion system,
it could be useful for the prevention and supplementary treatment of bacterial infections.
4. Obovatol inhibits the growth and aggressiveness of tongue squamous cell carcinoma through regulation of the EGF-mediated JAK-STAT signaling pathway.
5. Obovatol induces apoptosis via CHOP activation in A549 and H460 NSCLCs.
6. Obovatol inhibits receptor activator of nuclear factor kappa B (NF-κB) ligand (RANKL)-induced osteoclast differentiation in vitro and inflammatory bone loss in vivo, it may be a useful therapeutic agent for the treatment of pathological bone disorders characterized by excessive osteoclastic bone resorption.
7. Obovatol shows neuroprotective effects against glutamate-induced apoptotic stimuli in HT22 cells.
8. Obovatol has a potent antithrombotic effect, which may be due to antiplatelet activity.
9. Obovatol inhibits vascular smooth muscle cell proliferation and intimal hyperplasia by inducing p21Cip1, it may have potential as an anti-proliferative agent for the treatment of restenosis and atherosclerosis.

1. Lonicerin has both anti-arthritic and antifungal activities, it can result in a combination therapy for the treatment of fungal arthritis due to C. albicans infection.
2. Lonicerin has potential antioxidant effects.