Hot Natural Products & Bioactive Compounds

Cudraxanthone B is a natural product from Cudrania tricuspidata.

1. Norviburtinal possesses novel angiogenesis effect.
2. Norviburtinal and isopinnatal show in vitro cytotoxicity against cancer cell lines.
3. Norviburtinal has little selectivity for melanoma cell lines whilst isopinnatal also shows some cytotoxic activity.

1. 2-Methoxystypandrone displays an immunomodulatory effect in a cellular model.
2. 2-Methoxystypandrone specifically inhibits JAK and IKKβ kinase activities.
3. 2-Methoxystypandrone blocks inflammatory responses by impairing NF-κB signaling to limit the inflammation and oxidative stress for preservation of BBB integrity.
4. 2-Methoxystypandrone concomitantly promotes neurodevelopmental protein expression and endogenous neurogenesis through inactivation of GSK3β to enhance β-catenin signaling for upexpression of neuroprotective genes and proteins.
5. 2-Methoxystypandrone has anti-osteoclastogenic effect, could reflect the block of RANKL-induced association of TRAF6-TAK1 complexes with consequent decrease of IkappaB-mediated NF-kappaB and mitogen-activated protein kinases-mediated c-Fos activation pathways and suppression of NFATc1 and other gene expression, essential for bone resorption.

1. Trichorabdal A shows a very strong in vitro antibacterial activity against Helicobacter pylori.

Eupatorin has antiproliferative and antiangiogenic effects, it emerges as a promising agent in anticancer research.Eupatorin-induced cell death is mediated by both the extrinsic and the intrinsic apoptotic pathways and through a mechanism dependent on reactive oxygen species generation. Eupatorin also has meaningful anti-inflammatory property which may be utilized in the development of novel anti-inflammatory treatments.

Curculigoside has potent antioxidant, anti-osteoporotic, immunomodulatory, and neuroprotective effects. Curculigoside can improve cognitive function in aged animals, possibly by decreasing the activity of AchE in the cerebra and inhibiting the expression of BACE1 in the hippocampus. Curculigoside exhibits potent inhibitory activity against matrix metalloproteinase-1 in cultured human skin fibroblasts, and increases the levels of ALP and Runx2 in osteoblasts under oxidative stress via anti-oxidative character.

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prim-O-Glucosylangelicain is a natural product from Cimicifuga foetida L.