Hot Natural Products & Bioactive Compounds

Methyl cinnamate, a tyrosinase inhibitor and a flavoring compound, which has antimicrobial, antiadipogenic, vasorelaxant, and anti-inflammatory effects. It has a wide spectrum of targets including CaMKK2-AMPK, Ca(2+) channels.

Ethyl cinnamate has antifungal, and vasorelaxant effects, it can inhibit the tonic contractions induced by high K+ and phenylephrine (PE) in a concentration-dependent manner, with respective IC50 values of 0.30 +/- 0.05 mM and 0.38 +/- 0.04 mM. Ethyl cinnamate can lead to the damage of cell membrane system and metabolic disorder through inducing lipid peroxidation via initiating ROS overproduction.Ethyl cinnamate has acute inhibition to the maximum quantum yield and the potential activity of photosystem II of Chlorella pyrenoidosa.

Scopolamine is a high affinity (nM) muscarinic antagonist. 5-HT3 receptor-responses are reversibly inhibited by Scopolamine with an IC50 of 2.09 μM. Scopolamine can cause learning and memory impairments and galantamine can reverse the symptom.
It also can produce rapid and significant symptom improvement in patients with depression.

Lethedoside A was either inactive or weakly active against KB tumor cells, in contrast to previously isolated flavones from the same plant.

1. Podocarpusflavone A is the strongest noncytotoxic non-nucleotide molecule exhibiting a specific inhibitory activity against the RNA polymerase domain of DV-NS5 and thus is promising for chemotherapy development against dengue fever.
2. Podocarpusflavone A shows antimalarial activity in vitro against the chloroquine-sensitive
F32 and chloroquine-resistant FcM29 strains of Plasmodium falciparum.

Pinosylvin is likely to act as a pro-angiogenic factor, it has anti-inflammatory activity, it may be utilized as a phytotherapic agent for the prevention of cardiovascular inflammatory diseases. Pinosylvin is an effective inhibitor of neutrophil activity, and is potentially useful as a complementary medicine in states associated with persistent inflammation. Pinosylvin has protection against oxidative stress through the induction of HO-1 in human RPE cells. Pinosylvin has inhibition against White-Rot and Brown-Rot Fungi.

1. Cytochalasin D-induced extension of neurite-like processes might correlate with enhanced accumulation of PrPres.
2. Cytochalasin D is an actin inhibitor, the removal of actin stress fibers is crucial for the chondrogenic differentiation.
3. Cytochalasin D inhibits CT26 tumor growth potentially through inhibition of cell proliferation, induction of cell apoptosis and suppression of tumor angiogenesis.
4. Cytochalasin D stimulates the expression of TF in B16 melanoma cells, activating both coagulation-dependent and -independent pathways via binding to FVIIa, eventually promoting lung metastasis.
5. Cytochalasin D inhibits smooth muscle contraction by directly inhibiting contractile apparatus.
6. Cytochalasin D is an inhibitor of microfilament-dependent phagocytosis, it (0.5 or 1.0 micrograms/ml) can inhibit intracellular multiplication of L. pneumophila in U937 monocytes.
7. Cytochalasin D may be an inhibitor of some fertilization processes such as sperm penetration or sperm head decondensation.

1. 11-Hydroxytabersonine has antitumor activety.