Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCC6588 | (R)-(+)-HA-966 |
| Antagonist/partial agonist at the glycine site of the NMDA receptor; able to cross the blood-brain barrier. Also available as part of the NMDA Receptor - Glycine Site. S-enantiomer available. | |
| BCC6589 | (S)-(-)-HA-966 |
| Possesses potent sedative and ataxic action, probably through disruption of striatal dopaminergic mechanisms. R-enantiomer also available. | |
| BCC6591 | Ibotenic acid |
| NMDA and metabotropic glutamate receptor agonist. | |
| BCC6592 | 5,7-Dichlorokynurenic acid |
| Potent antagonist at the glycine site of the NMDA receptor (Ki = 79 nM vs. [3H]-glycine). Sodium salt also available. | |
| BCC6594 | N-(4-Hydroxyphenylacetyl)spermine |
| Wasp toxin analog. More potent than PhTX-343 at locust NMJ. Reported to be selective for NMDA receptors in mammalian CNS. | |
| BCC6595 | L-trans-2,4-PDC |
| Potent, competitive, transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor. Also available as part of the Excitatory Amino Acid Transporter Inhibitor. | |
| BCC6596 | (S)-(-)-5-Fluorowillardiine |
| A more potent and selective AMPA receptor agonist (at hGluR1 and hGluR2) than AMPA itself (Ki = 14.7, 25.1, and 1820 nM for hGluR1, hGluR2 and hGluR5 respectively). Also available as part of the AMPA Receptor Tocriset™. | |
| BCC6597 | (S)-(-)-5-Iodowillardiine |
| Demonstrates high affinity for the kainate receptor subtype hGluK1 (formerly hGluR5) (Ki = 0.24 nM) and 600-4000-fold selectivity over both the AMPA receptor subtypes and the homomeric kainate receptor hGluK2 (formerly hGluR6). | |
