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(RS)-AMPA hydrobromide

CAS# 171259-81-7

(RS)-AMPA hydrobromide

Catalog No. BCC6926----Order now to get a substantial discount!

Product Name & Size Price Stock
(RS)-AMPA hydrobromide: 5mg $598 In Stock
(RS)-AMPA hydrobromide: 10mg Please Inquire In Stock
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Chemical structure

(RS)-AMPA hydrobromide

3D structure

Chemical Properties of (RS)-AMPA hydrobromide

Cas No. 171259-81-7 SDF Download SDF
PubChem ID 11957558 Appearance Powder
Formula C7H11BrN2O4 M.Wt 267.08
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble to 10 mM in water with gentle warming
Chemical Name 2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid;hydrobromide
SMILES CC1=C(C(=O)NO1)CC(C(=O)O)N.Br
Standard InChIKey KUAHVIUZGLGASU-UHFFFAOYSA-N
Standard InChI InChI=1S/C7H10N2O4.BrH/c1-3-4(6(10)9-13-3)2-5(8)7(11)12;/h5H,2,8H2,1H3,(H,9,10)(H,11,12);1H
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of (RS)-AMPA hydrobromide

DescriptionMore water soluble hydrobromide salt of (RS)-AMPA.

(RS)-AMPA hydrobromide Dilution Calculator

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(RS)-AMPA hydrobromide Molarity Calculator

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Preparing Stock Solutions of (RS)-AMPA hydrobromide

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.7442 mL 18.721 mL 37.442 mL 74.8839 mL 93.6049 mL
5 mM 0.7488 mL 3.7442 mL 7.4884 mL 14.9768 mL 18.721 mL
10 mM 0.3744 mL 1.8721 mL 3.7442 mL 7.4884 mL 9.3605 mL
50 mM 0.0749 mL 0.3744 mL 0.7488 mL 1.4977 mL 1.8721 mL
100 mM 0.0374 mL 0.1872 mL 0.3744 mL 0.7488 mL 0.936 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on (RS)-AMPA hydrobromide

The binding of [3H]AMPA, a structural analogue of glutamic acid, to rat brain membranes.[Pubmed:6125564]

J Neurochem. 1982 Jan;38(1):173-8.

Binding of [3H]AMPA to rat brain membranes was investigated. The binding was saturable and reversible at physiological pH. Computer-aided Scatchard analysis of the binding data, as determined by using L-glutamic acid (L-GLU) to define nonspecific binding, suggested the presence of two independent binding sites, with KDS of 9 and 2440 nM, respectively. Additional freezing, thawing and washing sequences gave membranes with only one binding site, with a KD of 278 nM. [3H]AMPA binding exhibited the highest level in striatal membranes. A series of analogues of GLU and aspartic acid (ASP) were tested as inhibitors of [3H]AMPA binding. L-ASP and compounds which interact predominantly with N-methyl-D-aspartic acid (NMDA) receptor sites were inactive as inhibitors of [3H]AMPA binding, whereas L-GLU and compounds which interact predominantly with glutamic acid diethyl ester receptor sites were inhibitors with the same order of potency as that shown by the excitatory action in vivo. The result suggests that [3H]AMPA might represent binding to an excitatory GLU receptor.

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