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N-Methylquipazine dimaleate

5-HT3 agonist CAS# 171205-17-7

N-Methylquipazine dimaleate

Catalog No. BCC6697----Order now to get a substantial discount!

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Quality Control of N-Methylquipazine dimaleate

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Chemical structure

N-Methylquipazine dimaleate

3D structure

Chemical Properties of N-Methylquipazine dimaleate

Cas No. 171205-17-7 SDF Download SDF
PubChem ID 11957670 Appearance Powder
Formula C22H25N3O8 M.Wt 459.45
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble to 50 mM in water
Chemical Name (Z)-but-2-enedioic acid;2-(4-methylpiperazin-1-yl)quinoline
SMILES CN1CCN(CC1)C2=NC3=CC=CC=C3C=C2.C(=CC(=O)O)C(=O)O.C(=CC(=O)O)C(=O)O
Standard InChIKey HNSITEGFVDCKMF-SPIKMXEPSA-N
Standard InChI InChI=1S/C14H17N3.2C4H4O4/c1-16-8-10-17(11-9-16)14-7-6-12-4-2-3-5-13(12)15-14;2*5-3(6)1-2-4(7)8/h2-7H,8-11H2,1H3;2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of N-Methylquipazine dimaleate

Description5-HT3 agonist. Has almost the same affinity for 5-HT3 sites as quipazine but unlike the latter, does not bind to 5-HT1B sites.

N-Methylquipazine dimaleate Dilution Calculator

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Preparing Stock Solutions of N-Methylquipazine dimaleate

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.1765 mL 10.8826 mL 21.7652 mL 43.5303 mL 54.4129 mL
5 mM 0.4353 mL 2.1765 mL 4.353 mL 8.7061 mL 10.8826 mL
10 mM 0.2177 mL 1.0883 mL 2.1765 mL 4.353 mL 5.4413 mL
50 mM 0.0435 mL 0.2177 mL 0.4353 mL 0.8706 mL 1.0883 mL
100 mM 0.0218 mL 0.1088 mL 0.2177 mL 0.4353 mL 0.5441 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on N-Methylquipazine dimaleate

Binding of arylpiperazines to 5-HT3 serotonin receptors: results of a structure-affinity study.[Pubmed:2583244]

Eur J Pharmacol. 1989 Sep 22;168(3):387-92.

The binding affinities of a series of arylpiperazine derivatives at [3H]quipazine-labeled central 5-HT3 sites were investigated. Features determined to be important for binding include the N4 piperazine nitrogen atom (but not the N1 piperazine nitrogen), and a quinolinyl group. The quinoline nitrogen atom of quipazine also contributes to affinity and its replacement by carbon reduces affinity by 20-fold. The entire quinoline nucleus is not necessary for binding, and certain monocyclic arylpiperazines, particularly those with a chloro group meta to the position of the piperazine ring (e.g. mCPP, MK-212), also bind at 5-HT3, sites; however, the affinities of these agents are at least an order of magnitude less than that of quipazine itself. Taking advantage of the fact that tertiary amines are not well tolerated at 5-HT1B sites, but that N-methyl substituents have little effect on 5-HT3 binding, we designed and synthesized a tertiary amine analog of quipazine, i.e., N-methylquipazine (NMQ). NMQ binds at 5-HT3 sites with an affinity similar to that of quipazine; however, unlike quipazine, NMQ shows very little affinity (IC50 greater than 10,000 nM) for central 5-HT1B sites.

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