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Dibutyl Phthalate

CAS# 84-74-2

Dibutyl Phthalate

2D Structure

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Dibutyl Phthalate

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Chemical Properties of Dibutyl Phthalate

Cas No. 84-74-2 SDF Download SDF
PubChem ID 3026 Appearance Powder
Formula C16H22O4 M.Wt 278.3
Type of Compound Miscellaneous Storage Desiccate at -20°C
Synonyms Di-n-butyl phthalate
Solubility Ethanol : ≥ 50 mg/mL (179.64 mM)
*"≥" means soluble, but saturation unknown.
Chemical Name dibutyl benzene-1,2-dicarboxylate
SMILES CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC
Standard InChIKey DOIRQSBPFJWKBE-UHFFFAOYSA-N
Standard InChI InChI=1S/C16H22O4/c1-3-5-11-19-15(17)13-9-7-8-10-14(13)16(18)20-12-6-4-2/h7-10H,3-6,11-12H2,1-2H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Dibutyl Phthalate

The herbs of Salvia yunnanensis

Biological Activity of Dibutyl Phthalate

Description1,2-Benzenedicarboxylic acid is one kind of allelochemical shows stronger allelopathic effect on itself than on wheat and pigeonpea. 1,2-Benzenedicarboxylic acid has antimicrobial activity, it shows anti-extended-spectrum beta-lactamases (ESBL) activity.
TargetsAntifection
In vitro

Antimicrobial activity of 1,2-benzenedicarboxylic acid, butyldecyl ester isolated from the seeds and pods of Acacia nilotica Linn[Reference: WebLink]

Basic Research Journal of Microbiology, 2016 June, 3(2): 08-11.

The antimicrobial activity of 1,2-Benzenedicarboxylic acid, butyldecyl ester isolated from Acacia nilotica was determined using standard methods.
METHODS AND RESULTS:
The compound was isolated by directing the fractionation of ethyl acetate extract of the air dried seeds and pod with microbial sensitivity test. The results of the antibacterial screening showed that the ethyl acetate extract of Acacia nilotica Linn exhibited the highest activities against the test microbes with zones of inhibition diameter ranging from 27-32mm against Salmonela typhi, Escherichia coli, Streptococcus feacalis, Staphylococcus aureus, Candida krusei and Shigella dysentriae.
CONCLUSIONS:
The structure of the compound was identified from 13CNMR, 1HNMR, IR and GC-MS spectral data. The isolation, structural elucidation, NMR spectral assignment and bioactivities are reported.

In-Silico Analysis of Streptomyces sp secondary metabolite 1,2-Benzenedicarboxylic acid, mono (2-ethylhexyl) Ester with ESBL proteins[Reference: WebLink]

International Journal of Pharma & Bio Sciences, 2015 , 6 (1) :1190-1195.

The anti-ESBL activity of 1,2-Benzenedicarboxylic acid, mono (2-ethylhexyl) ester (DMEHE) extracted from marine Streptomyces sp strain VITSJK8 was further confirmed by in silico analysis.
METHODS AND RESULTS:
A total of 10 ESBL proteins was chosen for this study from the protein data bank (PDB) and were docked with the DMEHE. The resultant atomic contact energy (ACE) was compared with dockings of known antibiotic ertapenem, penicillin G, amoxicillin, rocephin and cefozopran. PatchDock online docking server was utilized for docking studies. LigPlot+ and PyMOL were used to evaluate the docking results obtained from PatchDock. The docking of DMEHE with ESBL proteins showed the ACE value range from -198.42 to 22.62, while docking of ertapenem showed the ACE value range from -217.67 to -71.8. DMEHE formed hydrogen bonds with AMPC, CTXM-9, TEM-1 and TEM-52 ESBL proteins. The interaction between DMEHE and ESBL protein complex was unstable and no covalent bond formation was observed, whereas ertapenem and ESBL complex was highly stable because of the covalent bond and hydrogen bond formation in the ligand-protein interaction. Similarly penicillin G, amoxicillin, rocephin and cefozopran also demonstrated higher stability with ESBL proteins compared to DMEHE.
CONCLUSIONS:
Based on this study, it could be concluded that bacterial proteins will not involve in lysis of DMEHE and therefore DMEHE would be an effective drug for treating the drug resistant ESBL pathogens.

Identification of root exudation of Zea mays L. and allelopathy of 1,2-benzenedicarboxylic acid[Reference: WebLink]

Journal of Gansu Agricultural University, 2007, 42(5):43-48.

Root exudation is one of the most important resources of allelochemical.
METHODS AND RESULTS:
In this study,the root exudation of Zea mays L.seedlings,which were cultivated in liquid,was extracted with C2Cl2 35 d ays after germination,and was identified by the way of gas chromatographymass spectrometry(GC-MS).At the same time,the biological characteristics of the typical exudation 1,2-Benzenedicarboxylic acid was tested through germination experiment.
CONCLUSIONS:
The results indicated that the component of the exudation mainly included hydrocarbon,benzene,thiazole,organic acid,ketone,amide,grease,mellow and phenol etc.The typical exudation 1,2-Benzenedicarboxylic acid as one kind of allelochemical showed stronger allelopathic effect on itself than on wheat and pigeonpea.

Dibutyl Phthalate Dilution Calculator

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Dibutyl Phthalate Molarity Calculator

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Preparing Stock Solutions of Dibutyl Phthalate

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.5932 mL 17.9662 mL 35.9324 mL 71.8649 mL 89.8311 mL
5 mM 0.7186 mL 3.5932 mL 7.1865 mL 14.373 mL 17.9662 mL
10 mM 0.3593 mL 1.7966 mL 3.5932 mL 7.1865 mL 8.9831 mL
50 mM 0.0719 mL 0.3593 mL 0.7186 mL 1.4373 mL 1.7966 mL
100 mM 0.0359 mL 0.1797 mL 0.3593 mL 0.7186 mL 0.8983 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Dibutyl Phthalate

The action mechanism and biocontrol potentiality of novel isolates of Saccharomyces cerevisiae against the aflatoxigenic Aspergillus flavus.[Pubmed:30554415]

Lett Appl Microbiol. 2019 Feb;68(2):104-111.

Inhibition of Aspergillus flavus growth and its aflatoxins production using the biocontrol agent Saccharomyces cerevisiae as well as to explore its mode of action was studied. Eight strains of S. cerevisiae strains were able to suppress the growth of A. flavus Z103. The maximum growth inhibition of A. flavus Z103 was obtained by living cells of S. cerevisiae EBF101 and S. cerevisiae 117 with 85 and 83%, respectively. The sporulation inhibition and hyphae deterioration of A. flavus Z103 by S. cerevisiae cells adhesion were observed under SEM; up to 99.8% inhibition of aflatoxins biosynthesis by A. flavus Z103 was resulted when the fungus was treated by autoclaved extracellular crude of S. cerevisiae. Also, the tested strains are potential to produce exo-chitinase which could be suggested as another mode of action for its antifungal activity. GC-MS analysis of S. cerevisiae 117 extracellular secondary metabolites revealed the existence of 4-Hydroxyphenethyl alcohol (46.32%), 4, 4-Dimethyloxazole (9.14%) and 1,2-Benzenedicarboxylic acid dioctyl ester (2.8%). Significance and Impact of the Study: The use of Saccharomyces cerevisiae instead of chemical preservatives in fermented food, animal and fish feed and storage cereal grains could encourage the food industry to produce organic food free of chemical additives. Overall, our data suggest the possibility of using S. cerevisiae as an alternative treatment in the food industries to control the dispersion and aflatoxins production by Aspergillus flavus during storage. This method could provide an additional probiotic effect in the digestive tract of consumers after ingestion of the treated food. So, our study clarifies the exact mechanisms responsible for the reduction of the aflatoxin contents by S. cerevisiae.

Description

Dibutyl phthalate is a commonly used plasticizer commonly found in some food packaging materials, personal care products, and the coating of oral medications. May cause toxicity and adverse neurobehavioral effects.

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