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Wilforlide A acetate

CAS# 84104-80-3

Wilforlide A acetate

Catalog No. BCN4384----Order now to get a substantial discount!

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Wilforlide A acetate: 5mg $886 In Stock
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Quality Control of Wilforlide A acetate

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Chemical structure

Wilforlide A acetate

3D structure

Chemical Properties of Wilforlide A acetate

Cas No. 84104-80-3 SDF Download SDF
PubChem ID 91895469 Appearance Powder
Formula C32H48O4 M.Wt 496.7
Type of Compound Triterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name [(1S,2R,5S,6R,9R,11S,14R,15R,19S,21S)-2,5,6,10,10,14,21-heptamethyl-22-oxo-23-oxahexacyclo[19.2.1.02,19.05,18.06,15.09,14]tetracos-17-en-11-yl] acetate
SMILES CC(=O)OC1CCC2(C(C1(C)C)CCC3(C2CC=C4C3(CCC5(C4CC6(CC5OC6=O)C)C)C)C)C
Standard InChIKey KCKCIDCRXAOGCM-KXWOPETLSA-N
Standard InChI InChI=1S/C32H48O4/c1-19(33)35-24-12-13-30(6)22(27(24,2)3)11-14-32(8)23(30)10-9-20-21-17-28(4)18-25(36-26(28)34)29(21,5)15-16-31(20,32)7/h9,21-25H,10-18H2,1-8H3/t21-,22-,23+,24-,25-,28-,29+,30-,31+,32+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Wilforlide A acetate

The herb of Tripterygium wilfordii Hook.f.

Biological Activity of Wilforlide A acetate

DescriptionWilforlide A (T1) serves as a quality control standard of Tripterygium Glycosides that be listed in Drug Standard of Ministry of Public Health of the People's Republic of China. T1 has anti-inflammatory effects.
In vitro

Comparative study on the anti-inflammatory and immune suppressive effect of Wilforlide A.[Reference: WebLink]

Fitoterapia, 2010, 81(8):1109-1112.

Tripterygium Glycosides (TG) is effective in the treatment of patients with a variety of inflammatory and autoimmune diseases, especially rheumatoid arthritis (RA) in clinical. Wilforlide A (T1) serves as a quality control standard of TG that be listed in Drug Standard of Ministry of Public Health of the People's Republic of China. The pharmacologic actions of T1 remain to be unidentified.
METHODS AND RESULTS:
In this paper, we studied the anti-inflammatory and immune suppressive effect of T1, and compared it with Triptolide (TP), which believed to be the major active component of TG. Carrageenan-induced rat pedal swelling, tampon-induced rat granulation, and mice ear inhibition rate of swelling trail results show that high-dose T1 has obvious anti-inflammatory effect. Colorimetric detection contents of hemolysin, carbon elimination from plasma of mice, mice delayed hypersensitivity immune, and organ index were measured.
CONCLUSIONS:
The results show that T1 has no significant immune suppressive activity, and there has a significant difference with TP and TG. Therefore, we think the content of TP also should be controlled as a supplement standard in order to ensure safe and effective medication.

Wilforlide A acetate Dilution Calculator

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Wilforlide A acetate Molarity Calculator

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Preparing Stock Solutions of Wilforlide A acetate

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.0133 mL 10.0664 mL 20.1329 mL 40.2658 mL 50.3322 mL
5 mM 0.4027 mL 2.0133 mL 4.0266 mL 8.0532 mL 10.0664 mL
10 mM 0.2013 mL 1.0066 mL 2.0133 mL 4.0266 mL 5.0332 mL
50 mM 0.0403 mL 0.2013 mL 0.4027 mL 0.8053 mL 1.0066 mL
100 mM 0.0201 mL 0.1007 mL 0.2013 mL 0.4027 mL 0.5033 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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