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1-Dehydro-6-gingerdione

CAS# 76060-35-0

1-Dehydro-6-gingerdione

Catalog No. BCN3265----Order now to get a substantial discount!

Product Name & Size Price Stock
1-Dehydro-6-gingerdione: 5mg $173 In Stock
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Quality Control of 1-Dehydro-6-gingerdione

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Chemical structure

1-Dehydro-6-gingerdione

3D structure

Chemical Properties of 1-Dehydro-6-gingerdione

Cas No. 76060-35-0 SDF Download SDF
PubChem ID 71401862 Appearance Powder
Formula C17H22O4 M.Wt 290.4
Type of Compound Phenols Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 1-(4-hydroxy-3-methoxyphenyl)dec-1-ene-3,5-dione
SMILES CCCCCC(=O)CC(=O)C=CC1=CC(=C(C=C1)O)OC
Standard InChIKey JUKHKHMSQCQHEN-UHFFFAOYSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 1-Dehydro-6-gingerdione

The rhizomes of Zingber officinale Rosc.

Biological Activity of 1-Dehydro-6-gingerdione

Description1. 1-Dehydro-6-gingerdione is 5-HT1A receptor partial agonists. 2. 1-Dehydro-6-gingerdione has antioxidant and anti-inflammatory activities. 3. 1-Dehydro-6-gingerdione significantly suppresses the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins in a concentration-dependent fashion.
TargetsPGE | NOS | COX

1-Dehydro-6-gingerdione Dilution Calculator

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1-Dehydro-6-gingerdione Molarity Calculator

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Preparing Stock Solutions of 1-Dehydro-6-gingerdione

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.4435 mL 17.2176 mL 34.4353 mL 68.8705 mL 86.0882 mL
5 mM 0.6887 mL 3.4435 mL 6.8871 mL 13.7741 mL 17.2176 mL
10 mM 0.3444 mL 1.7218 mL 3.4435 mL 6.8871 mL 8.6088 mL
50 mM 0.0689 mL 0.3444 mL 0.6887 mL 1.3774 mL 1.7218 mL
100 mM 0.0344 mL 0.1722 mL 0.3444 mL 0.6887 mL 0.8609 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 1-Dehydro-6-gingerdione

In vitro antioxidant and anti-inflammatory activities of 1-dehydro-[6]-gingerdione, 6-shogaol, 6-dehydroshogaol and hexahydrocurcumin.[Pubmed:22868095]

Food Chem. 2012 Nov 15;135(2):332-7.

Hexahydrocurcumin, 1-dehydro-[6]-gingerdione, 6-dehydroshogaol and 6-shogaol were evaluated for their antioxidant and anti-inflammatory activities in the present study. The relative antioxidant potencies of ginger compounds decreased in similar order of 1-dehydro-[6]-gingerdione, hexahydrocurcumin>6-shogaol>6-dehydroshogaol in both 1,1-diphenyl-2-picyrlhydrazyl (DPPH) radical-scavenging and trolox equivalent antioxidant capacity (TEAC) assays. All tested compounds could attenuate lipopolysaccharide (LPS)-elicited increase of prostaglandin E2 (PGE(2)) in murine macrophages (RAW 264.7) in a concentration-dependent manner but hexahydrocurcumin of 7muM and 6-shogaol of 7muM. The strongest inhibitory effect was observed for 6-dehydroshogaol and 6-shogaol at 14muM with the inhibition of 53.3% and 48.9%, respectively. Furthermore, both 6-dehydroshogaol and 1-dehydro-[6]-gingerdione significantly suppressed the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins in a concentration-dependent fashion. These results contribute to our theoretical understanding of the potential beneficial effects of consuming ginger as a food and/or dietary supplement.

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