Broussonin CCAS# 76045-49-3 |
Quality Control & MSDS
3D structure
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| Cas No. | 76045-49-3 | SDF | Download SDF |
| PubChem ID | 442289 | Appearance | Powder |
| Formula | C20H24O3 | M.Wt | 312.41 |
| Type of Compound | Phenols | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 4-[3-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]propyl]benzene-1,3-diol | ||
| SMILES | CC(=CCC1=C(C=CC(=C1)CCCC2=C(C=C(C=C2)O)O)O)C | ||
| Standard InChIKey | CMOZGCJOTGLPKO-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C20H24O3/c1-14(2)6-8-17-12-15(7-11-19(17)22)4-3-5-16-9-10-18(21)13-20(16)23/h6-7,9-13,21-23H,3-5,8H2,1-2H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The branch of Broussonetia papyrifera
| Description | 1. Broussonin C and broussin are antifungal compounds. 2. Broussonin C exerts simple reversible slow-binding inhibition against diphenolase. |
| Targets | Tyrosinase | Antifection |
Broussonin C Dilution Calculator
Broussonin C Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.2009 mL | 16.0046 mL | 32.0092 mL | 64.0184 mL | 80.023 mL |
| 5 mM | 0.6402 mL | 3.2009 mL | 6.4018 mL | 12.8037 mL | 16.0046 mL |
| 10 mM | 0.3201 mL | 1.6005 mL | 3.2009 mL | 6.4018 mL | 8.0023 mL |
| 50 mM | 0.064 mL | 0.3201 mL | 0.6402 mL | 1.2804 mL | 1.6005 mL |
| 100 mM | 0.032 mL | 0.16 mL | 0.3201 mL | 0.6402 mL | 0.8002 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Tyrosinase inhibitory effects of 1,3-diphenylpropanes from Broussonetia kazinoki.[Pubmed:19046886]
Bioorg Med Chem. 2009 Jan 1;17(1):35-41.
Six 1,3-diphenylpropanes exhibiting inhibitory activities against both the monophenolase and diphenolase actions of tyrosinase were isolated from the methanol (95%) extract of Broussonetia kazinoki. These compounds, 1-6, were identified as kazinol C (1), D (2), F (3), Broussonin C (4), kazinol S (5) and kazinol T (6). The latter two species (5 and 6) emerged to be new 1,3-diphenylpropanes which we fully spectroscopically characterized. The IC(50) values of compounds (1, 3-5) for monophenolase inhibition were determined to range between 0.43 and 17.9 microM. Compounds 1 and 3-5 also inhibited diphenolase significantly with IC(50) values of 22.8, 1.7, 0.57, and 26.9 microM, respectively. All four active tyrosinase inhibitors (1, 3-5) were competitive inhibitors. Interestigly they all mainfested simple reversible slow-binding inhibition against diphenolase. The most potent inhibitor, compound 4 diplayed the following kinetic parameters k(3)=0.0993 microM(-1)min(-1), k(4)=0.0048 min(-1), and K(i)(app)=0.0485 microM.
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