Hederacoside D

CAS# 760961-03-3

Hederacoside D

2D Structure

Catalog No. BCN2330----Order now to get a substantial discount!

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3D structure

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Hederacoside D

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Chemical Properties of Hederacoside D

Cas No. 760961-03-3 SDF Download SDF
PubChem ID 21630094 Appearance White powder
Formula C53H86O22 M.Wt 1075.2
Type of Compound Triterpenoids Storage Desiccate at -20°C
Synonyms Cauloside D
Solubility Soluble in DMSO and methanol; insoluble in water
Chemical Name [(2S,3R,4S,5S,6R)-6-[[(2R,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxymethyl]-3,4,5-trihydroxyoxan-2-yl] (4aS,6aR,6aS,6bR,8aR,9R,10S,12aR,14bS)-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-10-[(2S,3R,4S,5S)-3,4,5-trihydroxyoxan-2-yl]oxy-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate
SMILES CC1C(C(C(C(O1)OC2C(OC(C(C2O)O)OCC3C(C(C(C(O3)OC(=O)C45CCC(CC4C6=CCC7C8(CCC(C(C8CCC7(C6(CC5)C)C)(C)CO)OC9C(C(C(CO9)O)O)O)C)(C)C)O)O)O)CO)O)O)O
Standard InChIKey UEHILKCNLIKLEV-LXABABOZSA-N
Standard InChI InChI=1S/C53H86O22/c1-23-32(57)35(60)39(64)45(70-23)74-42-27(19-54)71-43(41(66)37(42)62)69-21-28-34(59)36(61)40(65)46(72-28)75-47(67)53-16-14-48(2,3)18-25(53)24-8-9-30-49(4)12-11-31(73-44-38(63)33(58)26(56)20-68-44)50(5,22-55)29(49)10-13-52(30,7)51(24,6)15-17-53/h8,23,25-46,54-66H,9-22H2,1-7H3/t23-,25-,26-,27+,28+,29+,30+,31-,32-,33-,34+,35+,36-,37+,38+,39+,40+,41+,42+,43+,44-,45-,46-,49-,50-,51+,52+,53-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Hederacoside D

1 Hedera sp. 2 Pulsatilla sp.

Biological Activity of Hederacoside D

DescriptionHederacoside D is a narural product from Hedera nepalensis.

Protocol of Hederacoside D

Structure Identification
J Sep Sci. 2016 Sep;39(17):3292-301.

Pharmacokinetic parameters of three active ingredients hederacoside C, hederacoside D, and ɑ-hederin in Hedera helix in rats.[Pubmed: 27377040 ]

In Hedera helix hederacoside C, Hederacoside D, and ɑ-hederin are three major bioactive saponins and play pivotal roles in the overall biological activity.
METHODS AND RESULTS:
In this study, a specific and sensitive ultra-high performance liquid chromatography with tandem mass spectrometry method has been developed and validated for the quantification of three major bioactive saponins in rat plasma. Chromatographic separation was performed on a reversed-phase Thermo Hypersil GOLD C18 column (2.1 mm × 50 mm, 1.9 μm) using a gradient mobile phase system of acetonitrile-water containing 0.1% formic acid. The assay was successfully applied to study the pharmacokinetic behavior of the three analytes in rats after oral and intravenous administration of a mixture of saponins (hederacoside C, Hederacoside D, and ɑ-hederin). Further research was performed to compare the pharmacokinetic behavior of the three analytes after the oral administration of a mixture of saponins and an extract of saponins from Hedera helix, and results showed that double peaks were evident on concentration-time profile for each of the three saponins.
CONCLUSIONS:
The difference in the pharmacokinetic characteristics of three saponins between a mixture of saponins and an extract of saponins from Hedera helix was found in rat, which would be beneficial for the preclinical research and clinical use of Hedera helix.

Hederacoside D Dilution Calculator

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Hederacoside D Molarity Calculator

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Preparing Stock Solutions of Hederacoside D

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 0.9301 mL 4.6503 mL 9.3006 mL 18.6012 mL 23.2515 mL
5 mM 0.186 mL 0.9301 mL 1.8601 mL 3.7202 mL 4.6503 mL
10 mM 0.093 mL 0.465 mL 0.9301 mL 1.8601 mL 2.3251 mL
50 mM 0.0186 mL 0.093 mL 0.186 mL 0.372 mL 0.465 mL
100 mM 0.0093 mL 0.0465 mL 0.093 mL 0.186 mL 0.2325 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on Hederacoside D

Hederacoside D is a triterpenoid saponin with hederagenin as the aglycone part. It has been isolated from the stem bark of Kalopanax pictus. It has a role as an anti-inflammatory agent and a plant metabolite. It is a pentacyclic triterpenoid, a triterpenoid saponin and a carboxylic ester. It derives from a hederagenin.Hederacoside D is one of the bioactive saponins from Hedera helix, and plays pivotal roles in the overall biological activity.

In Vivo:The pharmacokinetic behavior of Hederacoside D is successfully applied in rats after oral and intravenous administration[1].

References:
[1]. Yu M, et al. Pharmacokinetic parameters of three active ingredients hederacoside C, hederacoside D, and ɑ-hederin in Hedera helix in rats. J Sep Sci. 2016 Sep;39(17):3292-301.

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References on Hederacoside D

Pharmacokinetic parameters of three active ingredients hederacoside C, hederacoside D, and a-hederin in Hedera helix in rats.[Pubmed:27377040]

J Sep Sci. 2016 Sep;39(17):3292-301.

In Hedera helix hederacoside C, Hederacoside D, and a-hederin are three major bioactive saponins and play pivotal roles in the overall biological activity. In this study, a specific and sensitive ultra-high performance liquid chromatography with tandem mass spectrometry method has been developed and validated for the quantification of three major bioactive saponins in rat plasma. Chromatographic separation was performed on a reversed-phase Thermo Hypersil GOLD C18 column (2.1 mm x 50 mm, 1.9 mum) using a gradient mobile phase system of acetonitrile-water containing 0.1% formic acid. The assay was successfully applied to study the pharmacokinetic behavior of the three analytes in rats after oral and intravenous administration of a mixture of saponins (hederacoside C, Hederacoside D, and a-hederin). Further research was performed to compare the pharmacokinetic behavior of the three analytes after the oral administration of a mixture of saponins and an extract of saponins from Hedera helix, and results showed that double peaks were evident on concentration-time profile for each of the three saponins. The difference in the pharmacokinetic characteristics of three saponins between a mixture of saponins and an extract of saponins from Hedera helix was found in rat, which would be beneficial for the preclinical research and clinical use of Hedera helix.

Description

Hederacoside D is one of the bioactive saponins from Hedera helix, and plays pivotal roles in the overall biological activity.

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