GlucosylvitexinCAS# 76135-82-5 |
- Vitexin -4''-O-glucoside
Catalog No.:BCN3054
CAS No.:178468-00-3
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
Cas No. | 76135-82-5 | SDF | Download SDF |
PubChem ID | 56933064 | Appearance | Yellow powder |
Formula | C27H30O15 | M.Wt | 594.5 |
Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
Synonyms | 4-O-Glucosylvitexin | ||
Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
Chemical Name | 8-[(3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one | ||
SMILES | C1=CC(=CC=C1C2=CC(=O)C3=C(O2)C(=C(C=C3O)O)C4C(C(C(C(O4)CO)OC5C(C(C(C(O5)CO)O)O)O)O)O)O | ||
Standard InChIKey | NDSUKTASTPEKBX-YGBVHABKSA-N | ||
Standard InChI | InChI=1S/C27H30O15/c28-7-15-19(34)20(35)23(38)27(41-15)42-24-16(8-29)40-26(22(37)21(24)36)18-12(32)5-11(31)17-13(33)6-14(39-25(17)18)9-1-3-10(30)4-2-9/h1-6,15-16,19-24,26-32,34-38H,7-8H2/t15-,16-,19-,20+,21-,22-,23-,24-,26?,27+/m1/s1 | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Description | Glucosylvitexin can inhibit thyroid peroxidase (TPO) activity, thus it can produce goitrogenic and antithyroid effects similar to those of certain other antithyroid agents and small doses of methimazole (MMI). |
In vivo | Antithyroid and goitrogenic effects of millet: role of C-glycosylflavones.[Pubmed: 2921306]J Clin Endocrinol Metab. 1989 Apr;68(4):707-14.Pearl millet [Pennisetum millet (L.) leeke] is the main source of food energy for the rural poor in many areas of the semiarid tropics. Epidemiological evidence suggests that millet may play a role in the genesis of endemic goiter in these areas, and sparse experimental data in rats support this suspicion. |
Glucosylvitexin Dilution Calculator
Glucosylvitexin Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 1.6821 mL | 8.4104 mL | 16.8209 mL | 33.6417 mL | 42.0521 mL |
5 mM | 0.3364 mL | 1.6821 mL | 3.3642 mL | 6.7283 mL | 8.4104 mL |
10 mM | 0.1682 mL | 0.841 mL | 1.6821 mL | 3.3642 mL | 4.2052 mL |
50 mM | 0.0336 mL | 0.1682 mL | 0.3364 mL | 0.6728 mL | 0.841 mL |
100 mM | 0.0168 mL | 0.0841 mL | 0.1682 mL | 0.3364 mL | 0.4205 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- 8-Hydroxy-DPAT hydrobromide
Catalog No.:BCC6681
CAS No.:76135-31-4
- 7-Hydroxy-DPAT hydrobromide
Catalog No.:BCC6756
CAS No.:76135-30-3
- Phaseollidin hydrate
Catalog No.:BCN3962
CAS No.:76122-57-1
- Solithromycin
Catalog No.:BCC6446
CAS No.:760981-83-7
- Hederacoside D
Catalog No.:BCN2330
CAS No.:760961-03-3
- Enalapril maleate
Catalog No.:BCC8955
CAS No.:76095-16-4
- SCH 28080
Catalog No.:BCC7154
CAS No.:76081-98-6
- Artocarpin
Catalog No.:BCN4309
CAS No.:7608-44-8
- Myricoside
Catalog No.:BCC8342
CAS No.:76076-04-5
- 1-Dehydro-6-gingerdione
Catalog No.:BCN3265
CAS No.:76060-35-0
- Broussonin C
Catalog No.:BCN4588
CAS No.:76045-49-3
- 3-Epikatonic acid
Catalog No.:BCN4308
CAS No.:76035-62-6
- Ipragliflozin
Catalog No.:BCC5137
CAS No.:761423-87-4
- ALK inhibitor 1
Catalog No.:BCC1339
CAS No.:761436-81-1
- TAE226 (NVP-TAE226)
Catalog No.:BCC3885
CAS No.:761437-28-9
- ALK inhibitor 2
Catalog No.:BCC1340
CAS No.:761438-38-4
- TAE684 (NVP-TAE684)
Catalog No.:BCC3660
CAS No.:761439-42-3
- Mildronate
Catalog No.:BCC2289
CAS No.:76144-81-5
- TCPOBOP
Catalog No.:BCC6979
CAS No.:76150-91-9
- Derrone
Catalog No.:BCN4587
CAS No.:76166-59-1
- Piptocarphin F
Catalog No.:BCN6447
CAS No.:76215-53-7
- 5-Deoxycajanin
Catalog No.:BCN4310
CAS No.:7622-53-9
- Ehretinine
Catalog No.:BCN1994
CAS No.:76231-29-3
- 15-Hydroxyferruginol
Catalog No.:BCN3294
CAS No.:76235-93-3
Antithyroid and goitrogenic effects of millet: role of C-glycosylflavones.[Pubmed:2921306]
J Clin Endocrinol Metab. 1989 Apr;68(4):707-14.
Pearl millet [Pennisetum millet (L.) leeke] is the main source of food energy for the rural poor in many areas of the semiarid tropics. Epidemiological evidence suggests that millet may play a role in the genesis of endemic goiter in these areas, and sparse experimental data in rats support this suspicion. This study was undertaken to determine in vivo in rats and in vitro using porcine thyroid slices and a thyroid peroxidase (TPO) assay the goitrogenic and antithyroid effects of millet diets, extracts of millet, and certain pure compounds contained therein. For use in these studies, whole grain millet was progressively dehulled to yield successively four bran and four flour fractions in which direct analyses revealed progressively lower concentrations of C-glycosylflavones. In vivo feeding of bran fraction 1, that richest in C-glycosylflavones, led to a significant increase in thyroid weight and antithyroid effects. Feeding of bran fraction 2, the next richest in C-glycosylflavones, produced similar, but less marked, changes. In vitro studies of 125I metabolism using porcine thyroid slices indicated that extracts of bran fractions 1 and 2 were most potent, producing changes similar to those produced by methimazole (MMI). At a concentration of 60 mumol/L, Glucosylvitexin, the major C-glycosylflavone present in millet, had effects comparable to those of 1 mumol/L MMI. Similarly, in studies of porcine TPO, extracts of bran fraction 1 caused pronounced (85%) inhibition of enzyme activity, and progressively less inhibition was induced by extracts of bran fractions 2, 3, and 4. Overall, the TPO-inhibiting activities of the various millet fractions closely correlated with their C-glycosylflavone concentrations. Three C-glycosylflavones present concentrations. Three C-glycosylflavones present in millet, Glucosylvitexin, glycosylorientin, and vitexin, also inhibited TPO activity. Thus, in vivo and in vitro studies revealed that millet diets rich in C-glycosylflavones produce goitrogenic and antithyroid effects similar to those of certain other antithyroid agents and small doses of MMI. We conclude that in areas of iodine deficiency in which millet is a major component of the diet, its ingestion may contribute to the genesis of endemic goiter.