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Conopharyngine

CAS# 76-98-2

Conopharyngine

2D Structure

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3D structure

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Conopharyngine

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Chemical Properties of Conopharyngine

Cas No. 76-98-2 SDF Download SDF
PubChem ID 65572 Appearance Powder
Formula C23H30N2O4 M.Wt 398.5
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CCC1CC2CC3(C1N(C2)CCC4=C3NC5=CC(=C(C=C45)OC)OC)C(=O)OC
Standard InChIKey DUFLXLVGASPEMV-COUHDALUSA-N
Standard InChI InChI=1S/C23H30N2O4/c1-5-14-8-13-11-23(22(26)29-4)20-15(6-7-25(12-13)21(14)23)16-9-18(27-2)19(28-3)10-17(16)24-20/h9-10,13-14,21,24H,5-8,11-12H2,1-4H3/t13?,14-,21-,23+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Conopharyngine

The herbs of Voacanga africana

Biological Activity of Conopharyngine

DescriptionStandard reference
In vivo

Structure-activity relationships of intracerebrally injected tremorigenic indole alkaloids.[Reference: WebLink]

Neuropharmacology.1973 Mar;12(3):239-244.


METHODS AND RESULTS:
The indole alkaloids harmane, harmine, ibogaine, iboxygaine and ibogaline caused tremor in mice when injected intracerebrally. Harmol, voacangine, voacristine and Conopharyngine were inactive in this respect. Chemical structure strongly influences tremorigenic potency which is increased by a methoxy group and reduced or abolished by a hydroxy or carbomethoxy group.
CONCLUSIONS:
The great importance of chemical structure for tremorigenic power of indole alkaloids points to specific receptors for these drugs in the brain.

Protocol of Conopharyngine

Structure Identification
Helvetica Chimica Acta.1975; 58(1):211–230.

Über Umwandlungen der Iboga-Alkaloide Voacangin und Conopharyngin 154. Mitteilung über Alkaloide.[Reference: WebLink]


METHODS AND RESULTS:
The reduction products voacanginol (3) and conopharynginol (4), obtained from the indole alkaloids voacangine (1) and Conopharyngine (2) respectively, gave, by the treatment of their tosylates 5 und 6 with triethylamine, two fragmentation products, voaenamine (7) (70–80%) and conoenamine (8) (25–45%) respectively (Scheme 1).
CONCLUSIONS:
The structures of 7 and 8 were derived from spectroscopic evidence and some chemical transformations.

Conopharyngine Dilution Calculator

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Preparing Stock Solutions of Conopharyngine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.5094 mL 12.5471 mL 25.0941 mL 50.1882 mL 62.7353 mL
5 mM 0.5019 mL 2.5094 mL 5.0188 mL 10.0376 mL 12.5471 mL
10 mM 0.2509 mL 1.2547 mL 2.5094 mL 5.0188 mL 6.2735 mL
50 mM 0.0502 mL 0.2509 mL 0.5019 mL 1.0038 mL 1.2547 mL
100 mM 0.0251 mL 0.1255 mL 0.2509 mL 0.5019 mL 0.6274 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Conopharyngine

Phytochemical investigation of Tabernaemontana crassa.[Pubmed:4094474]

J Ethnopharmacol. 1985 Nov-Dec;14(2-3):315-8.

From the stembark of Tabernaemontana crassa the alkaloid ibogaine was isolated as the major component. Ibogaine showed activity against the gram-positive Bacillus subtilis. Conopharyngine was identified as one of the minor compounds.

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