11-Hydroxycanthin-6-oneCAS# 75969-83-4 |
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| Cas No. | 75969-83-4 | SDF | Download SDF |
| PubChem ID | 337601 | Appearance | Yellow powder |
| Formula | C14H8N2O2 | M.Wt | 236.2 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | C1=CC(=O)C2=C3C=CNC4=C3N(C2=C1)C(=O)C=C4 | ||
| Standard InChIKey | IZNXKZBIIFOWPU-UHFFFAOYSA-N | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 11-Hydroxy-canthin-6-one has antineoplastic activity. |
| Structure Identification | Tetrahedron, 1988, 44(11):3349-54.Antineoplastic agents 157. Quassia kerstingII1[Reference: WebLink]The oxacanthin alkaloid components of Quassia kerstingü L. have been found to be 2-hydroxy- and 11-Hydroxycanthin-6-one (1a and 1b).
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11-Hydroxycanthin-6-one Dilution Calculator
11-Hydroxycanthin-6-one Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.2337 mL | 21.1685 mL | 42.337 mL | 84.674 mL | 105.8425 mL |
| 5 mM | 0.8467 mL | 4.2337 mL | 8.4674 mL | 16.9348 mL | 21.1685 mL |
| 10 mM | 0.4234 mL | 2.1169 mL | 4.2337 mL | 8.4674 mL | 10.5843 mL |
| 50 mM | 0.0847 mL | 0.4234 mL | 0.8467 mL | 1.6935 mL | 2.1169 mL |
| 100 mM | 0.0423 mL | 0.2117 mL | 0.4234 mL | 0.8467 mL | 1.0584 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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[A new indole alkaloid from the stems of Brucea mollis].[Pubmed:24761613]
Yao Xue Xue Bao. 2014 Feb;49(2):225-9.
Eight compounds were isolated from the stems of Brucea mollis by various chromatographic techniques such as column chromatography on silica gel and Sephadex LH-20, and preparative HPLC, and their structures were elucidated as bruceolline O (1), 1-(1-beta-glucopyranosyl)-1H-indole-3-carbaldehyde (2), canthin-6-one (3), 11-Hydroxycanthin-6-one (4), 9-methoxycanthin-6-one (5), 4-methoxycanthin-6-one (6), infractin (7), and beta-carboline-1-propionic acid (8). The cytotoxic activities of compounds 1-8 against HCT-8 and A549 human cell lines were determined, but none of them exhibited significant activity (IC 50 > 10 micromol x L(-1)). Among them, compound 1 is a new indole alkaloid, and compounds 2 and 5-7 were isolated from this plant for the first time.
[Study on chemical constituents of Picrasma quassioides].[Pubmed:21761728]
Zhongguo Zhong Yao Za Zhi. 2011 Apr;36(7):886-90.
To study the chemical constituents of Picrasma quassioides. The chemical constituents were isolated and purified by chromatographic methods over Sephadex LH-20 and silica gel column, and structurally elucidated by spectral analysis, including UV, IR, MS, 1H-NMR, 13C-NMR. Fourteen compounds were obtained and identified as trifolirhizin(1), maackiain(2), 3', 7-dihydroxy-4'-methoxylisoflavone(3), umbelliferone(4), emodin(5), nigakilactone F(6), picrasin B(7),picraqualide B (8),4-methoxy-5-hydroxycanthin-6-one(9), 4,5-dimethoxycanthin-6-one (10),5-methoxycanthin-6-one(11), 11-Hydroxycanthin-6-one(12) , 1-methoxycarbonyl-beta-carboline(13), 1-hydroxymethyl-beta-carboline(14). Compounds 1-5 are reported from the first time for the genus Pricrasma.
Canthin-6-one alkaloids from Brucea mollis var. tonkinensis.[Pubmed:7765437]
Phytochemistry. 1994 Aug;36(6):1543-6.
Three new alkaloids were isolated from the root-wood of Brucea mollis var. tonkinensis collected in China. Their structures were determined to be 11-O-beta-D-glucopyranosyl-(1-->6)-beta- D-glucopyranosylcanthin-6-one, 5-O-beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranosylcanthin-6-o ne and 11-Hydroxycanthin-6-one-N-oxide, by chemical and spectral methods. In addition, two known alkaloids, canthin-6-one and canthin-6-one-N-oxide, were isolated.
Production of canthin-6-one alkaloids by cell suspension cultures of Brucea javanica (L.) Merr.[Pubmed:24226822]
Plant Cell Rep. 1990 Sep;9(5):261-3.
Cell suspension cultures of Brucea javanica (L.) Merr. were used to determine culture growth characteristics and production of canthin-6-one alkaloids. The major alkaloids produced were canthin-6-one, 11-Hydroxycanthin-6-one, 5-methoxycanthin-6-one and 11-methoxycanthin-6-one. Alkaloids were synthesised throughout the 36 day growth cycle of the cells with maximum amounts within the cells occurring between days 20 to 28; approximately 10% of the alkaloids were in the medium at day 24 rising to 45% at day 32.
Antitumor agents, 79. Cytotoxic antileukemic alkaloids from Brucea antidysenterica.[Pubmed:3760882]
J Nat Prod. 1986 May-Jun;49(3):428-34.
Two cytotoxic antileukemic alkaloids, the new 1,11-dimethoxycanthin-6-one (3) and the known 11-Hydroxycanthin-6-one (1), as well as the known canthin-6-one (2) were isolated from the stem of Brucea antidysenterica. The structures of 1-3 were determined from their spectral data and X-ray analysis of the o-bromobenzoate of 1.
