Eupalinilide D

CAS# 757202-14-5

Eupalinilide D

Catalog No. BCN2523----Order now to get a substantial discount!

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Eupalinilide D: 5mg $207 In Stock
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Quality Control of Eupalinilide D

Number of papers citing our products

Chemical structure

Eupalinilide D

3D structure

Chemical Properties of Eupalinilide D

Cas No. 757202-14-5 SDF Download SDF
PubChem ID 11347578 Appearance Cryst.
Formula C15H19ClO5 M.Wt 314.76
Type of Compound Sesquiterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (3aR,4R,6R,6aS,7R,9aR,9bR)-6-(chloromethyl)-4,6,7-trihydroxy-9-methyl-3-methylidene-4,5,6a,7,9a,9b-hexahydro-3aH-azuleno[4,5-b]furan-2-one
SMILES CC1=CC(C2C1C3C(C(CC2(CCl)O)O)C(=C)C(=O)O3)O
Standard InChIKey JNRJLCSYIQFLDS-DKLFCYGSSA-N
Standard InChI InChI=1S/C15H19ClO5/c1-6-3-8(17)12-10(6)13-11(7(2)14(19)21-13)9(18)4-15(12,20)5-16/h3,8-13,17-18,20H,2,4-5H2,1H3/t8-,9-,10+,11-,12-,13-,15+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Eupalinilide D

The herbs of Eupatorium lindleyanum DC.

Biological Activity of Eupalinilide D

DescriptionEupalinilide D is a natural product from Impatiens balsamina L.

Protocol of Eupalinilide D

Structure Identification
J Nat Prod. 2004 Sep;67(9):1470-5.

Cytotoxic sesquiterpene lactones from Eupatorium lindleyanum.[Pubmed: 15387644]


METHODS AND RESULTS:
Ten new guaiane type sesquiterpene lactones, namely, Eupalinilide A, Eupalinilide B , Eupalinilide C, Eupalinilide D, Eupalinilide E, Eupalinilide F, Eupalinilide G, Eupalinilide H, Eupalinilide I, Eupalinilide J (1-10), as well as nine known compounds, eupachinilide C (11), eupachifolin D (12), eupachinilide E (13), 2alpha-hydroxyeupatolide (14), 3-deacetyleupalinin A (15), heliangine (16), 8beta-tigloyloxy-2,3-seco-6betaH,7alphaH-helianga-4Z,11(13)-diene-3,10beta;6, 12-diolid-2-oic acid (17), 8beta-(4'-hydroxytigloyloxy)-3beta,14-dihydroxy-6betaH,7alphaH-germacra-1(10)Z,4Z,11(13)-trien-6,12-olide (18), and 8beta-tigloyloxy-3beta,14-dihydroxy-6betaH,7alphaH-germacra-1(10)Z,4E,11(13)-trien-6,12-olide (19), were isolated from the whole plant of Eupatorium lindleyanum. Eupalinilide B (2), Eupalinilide C (3), Eupalinilide E (5), Eupalinilide F (6), and Eupalinilide I (9) have been tested for cytotoxicity against P-388 and A-549 tumor cell lines.
CONCLUSIONS:
The results showed that eupalinilide B (2) and Eupalinilide E (5) demonstrated potent cytotoxicity. The structures of these compounds were determined by spectroscopic methods including 1D and 2D NMR spectra.

Eupalinilide D Dilution Calculator

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Eupalinilide D Molarity Calculator

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Preparing Stock Solutions of Eupalinilide D

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.177 mL 15.8851 mL 31.7702 mL 63.5405 mL 79.4256 mL
5 mM 0.6354 mL 3.177 mL 6.354 mL 12.7081 mL 15.8851 mL
10 mM 0.3177 mL 1.5885 mL 3.177 mL 6.354 mL 7.9426 mL
50 mM 0.0635 mL 0.3177 mL 0.6354 mL 1.2708 mL 1.5885 mL
100 mM 0.0318 mL 0.1589 mL 0.3177 mL 0.6354 mL 0.7943 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Eupalinilide D

Cytotoxic sesquiterpene lactones from Eupatorium lindleyanum.[Pubmed:15387644]

J Nat Prod. 2004 Sep;67(9):1470-5.

Ten new guaiane type sesquiterpene lactones, namely, eupalinilides A-J (1-10), as well as nine known compounds, eupachinilide C (11), eupachifolin D (12), eupachinilide E (13), 2alpha-hydroxyeupatolide (14), 3-deacetyleupalinin A (15), heliangine (16), 8beta-tigloyloxy-2,3-seco-6betaH,7alphaH-helianga-4Z,11(13)-diene-3,10beta;6, 12-diolid-2-oic acid (17), 8beta-(4'-hydroxytigloyloxy)-3beta,14-dihydroxy-6betaH,7alphaH-germacra-1(10)Z,4Z ,11(13)-trien-6,12-olide (18), and 8beta-tigloyloxy-3beta,14-dihydroxy-6betaH,7alphaH-germacra-1(10)Z,4E,11(13)-trie n-6,12-olide (19), were isolated from the whole plant of Eupatorium lindleyanum. Eupalinilides B (2), C (3), E (5), F (6), and I (9) have been tested for cytotoxicity against P-388 and A-549 tumor cell lines. The results showed that eupalinilides B (2) and E (5) demonstrated potent cytotoxicity. The structures of these compounds were determined by spectroscopic methods including 1D and 2D NMR spectra.

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