1-MonopalmitinCAS# 542-44-9 |
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| Cas No. | 542-44-9 | SDF | Download SDF |
| PubChem ID | 14900 | Appearance | Powder |
| Formula | C19H38O4 | M.Wt | 330.50 |
| Type of Compound | Miscellaneous | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 2,3-dihydroxypropyl hexadecanoate | ||
| SMILES | CCCCCCCCCCCCCCCC(=O)OCC(CO)O | ||
| Standard InChIKey | QHZLMUACJMDIAE-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C19H38O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19(22)23-17-18(21)16-20/h18,20-21H,2-17H2,1H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The fruits of bitter melon.
| Description | 1. 1-Monopalmitin has dielectric properties. 2. 1-Monopalmitin inhibits the P-glycoprotein activity in intestinal Caco-2 cells. |
| Targets | P-gp |
1-Monopalmitin Dilution Calculator
1-Monopalmitin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.0257 mL | 15.1286 mL | 30.2572 mL | 60.5144 mL | 75.643 mL |
| 5 mM | 0.6051 mL | 3.0257 mL | 6.0514 mL | 12.1029 mL | 15.1286 mL |
| 10 mM | 0.3026 mL | 1.5129 mL | 3.0257 mL | 6.0514 mL | 7.5643 mL |
| 50 mM | 0.0605 mL | 0.3026 mL | 0.6051 mL | 1.2103 mL | 1.5129 mL |
| 100 mM | 0.0303 mL | 0.1513 mL | 0.3026 mL | 0.6051 mL | 0.7564 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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A bitter melon extract inhibits the P-glycoprotein activity in intestinal Caco-2 cells: monoglyceride as an active compound.[Pubmed:15630255]
Biofactors. 2004;22(1-4):71-4.
P-glycoprotein (P-gp) is a 170 kDa membrane protein that belongs to the ATP-binding cassette (ABC) transporter superfamily. In normal tissues, P-gp functions as an ATP-dependent efflux pump that excretes highly hydrophobic xenobiotic compounds, playing an important role in protecting the cells/tissues from xenobiotics. In the present study, chemical substances that could directly modulate the intestinal P-gp activity were searched in vegetables and fruits. By using human intestinal epithelial Caco-2 cells as a model of the small intestinal cells, we observed that a bitter melon fraction extracted from 40% methanol showed the greatest increase of the rhodamine-123 accumulation by Caco-2 cells. Inhibitory compounds in the bitter melon fraction were then isolated by HPLC using Pegasil C4 and Pegasil ODS columns. The HPLC fraction having the highest activity was analyzed by (1)H-NMR and FAB-MS, and the active compound was identified as 1-Monopalmitin. It is interesting that certain types of monoglyceride might be involved in the drug bioavailability by specifically inhibiting the efflux mediated by P-gp.
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