2'-Acetyltaxol

CAS# 92950-40-8

2'-Acetyltaxol

Catalog No. BCX1452----Order now to get a substantial discount!

Product Name & Size Price Stock
2'-Acetyltaxol: 5mg Please Inquire In Stock
2'-Acetyltaxol: 10mg Please Inquire In Stock
2'-Acetyltaxol: 20mg Please Inquire Please Inquire
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2'-Acetyltaxol: 100mg Please Inquire Please Inquire
2'-Acetyltaxol: 200mg Please Inquire Please Inquire
2'-Acetyltaxol: 500mg Please Inquire Please Inquire
2'-Acetyltaxol: 1000mg Please Inquire Please Inquire

Quality Control of 2'-Acetyltaxol

Number of papers citing our products

Chemical structure

2'-Acetyltaxol

3D structure

Chemical Properties of 2'-Acetyltaxol

Cas No. 92950-40-8 SDF Download SDF
PubChem ID 124951.0 Appearance Powder
Formula C49H53NO15 M.Wt 895.96
Type of Compound Diterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name [(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-diacetyloxy-15-[(2R,3S)-2-acetyloxy-3-benzamido-3-phenylpropanoyl]oxy-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate
SMILES CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)OC(=O)C)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C
Standard InChIKey IHVCSECZNFZVKP-XOVTVWCYSA-N
Standard InChI InChI=1S/C49H53NO15/c1-26-33(63-45(58)39(62-28(3)52)37(30-17-11-8-12-18-30)50-43(56)31-19-13-9-14-20-31)24-49(59)42(64-44(57)32-21-15-10-16-22-32)40-47(7,34(54)23-35-48(40,25-60-35)65-29(4)53)41(55)38(61-27(2)51)36(26)46(49,5)6/h8-22,33-35,37-40,42,54,59H,23-25H2,1-7H3,(H,50,56)/t33-,34-,35+,37-,38+,39+,40-,42-,47+,48-,49+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 2'-Acetyltaxol

Taxus chinensis (Pilger) Rehd.

2'-Acetyltaxol Dilution Calculator

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2'-Acetyltaxol Molarity Calculator

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Preparing Stock Solutions of 2'-Acetyltaxol

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.1161 mL 5.5806 mL 11.1612 mL 22.3224 mL 27.903 mL
5 mM 0.2232 mL 1.1161 mL 2.2322 mL 4.4645 mL 5.5806 mL
10 mM 0.1116 mL 0.5581 mL 1.1161 mL 2.2322 mL 2.7903 mL
50 mM 0.0223 mL 0.1116 mL 0.2232 mL 0.4464 mL 0.5581 mL
100 mM 0.0112 mL 0.0558 mL 0.1116 mL 0.2232 mL 0.279 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 2'-Acetyltaxol

Modified taxols, 4. Synthesis and biological activity of taxols modified in the side chain.[Pubmed:2898009]

J Nat Prod. 1988 Mar-Apr;51(2):298-306.

A number of taxol derivatives substituted at the 2' position of the side chain have been prepared and their biological activities determined in KB cell culture and/or the P-388 in vivo assay. The 2'-(t-butyldimethylsilyl)taxol 5 is essentially inactive, indicating the need for a free hydroxyl group at the 2' position for activity. Epimerization of the 2' position occurred on treatment of 2'-acetyltaxol derivatives with 1,5-diazabicyclo[5.4.0]undec-7-ene, but treatment of 2'-(2,2,2-trichloroethyloxycarbonyl) taxol derivatives with DBU yielded the novel cyclization products 11 and 12 and, after deprotection at the 7 position, 13. The derivative 13 is also essentially inactive in the KB test system. Two taxols with increased H2O solubility were prepared, the 2'-(beta-alanyl) derivative 15 and the 2'-succinyl derivative 16. Although both these derivatives were active in vivo and in vitro, the former was too unstable and the latter not active enough to make suitable H2O-soluble derivatives of taxol.

Preparation and biological activity of taxol acetates.[Pubmed:6548627]

Biochem Biophys Res Commun. 1984 Oct 30;124(2):329-36.

Synthesis and biological activity of 2'-acetyltaxol and 7-acetyltaxol are reported. Activity is measured in vivo by cytotoxicity toward the macrophage-like cell line J774.2, and in vitro by promotion of microtubule assembly in the absence of exogenous GTP. Addition of an acetyl moiety at C-2' results in loss of in vitro activity but not cytotoxicity. The properties of 7-acetyltaxol are similar to those of taxol in its effects on cell replication and on in vitro microtubule polymerization. Therefore a free hydroxyl group at C-7 is not required for in vitro activity and this position is available for structural modifications.

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