Methyl cis-11-eicosenoateCAS# 2390-09-2 |
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| Cas No. | 2390-09-2 | SDF | Download SDF |
| PubChem ID | N/A | Appearance | Powder |
| Formula | C21H40O2 | M.Wt | 324.55 |
| Type of Compound | Aliphatics | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Methyl cis-11-eicosenoate Dilution Calculator
Methyl cis-11-eicosenoate Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.0812 mL | 15.4059 mL | 30.8119 mL | 61.6238 mL | 77.0297 mL |
| 5 mM | 0.6162 mL | 3.0812 mL | 6.1624 mL | 12.3248 mL | 15.4059 mL |
| 10 mM | 0.3081 mL | 1.5406 mL | 3.0812 mL | 6.1624 mL | 7.703 mL |
| 50 mM | 0.0616 mL | 0.3081 mL | 0.6162 mL | 1.2325 mL | 1.5406 mL |
| 100 mM | 0.0308 mL | 0.1541 mL | 0.3081 mL | 0.6162 mL | 0.7703 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Metabolomic Profiling of the Immune Stimulatory Effect of Eicosenoids on PMA-Differentiated THP-1 Cells.[Pubmed:31600945]
Vaccines (Basel). 2019 Oct 9;7(4):142.
Honey bee venom has been established to have significant effect in immunotherapy. In the present study, (Z)-11-eicosenol-a major constituent of bee venom, along with its derivations Methyl cis-11-eicosenoate and cis-11-eicosenoic acid, were synthesised to investigate their immune stimulatory effect and possible use as vaccine adjuvants. Stimuli that prime and activate the immune system have exerted profound effects on immune cells, particularly macrophages; however, the effectiveness of bee venom constituents as immune stimulants has not yet been established. Here, the abilities of these compounds to act as pro-inflammatory stimuli were assessed, either alone or in combination with lipopolysaccharide (LPS), by examining the secretion of tumour necrosis factor-alpha (TNF-alpha) and the cytokines interleukin-1beta (IL-1beta), IL-6 and IL-10 by THP-1 macrophages. The compounds clearly increased the levels of IL-1beta and decreased IL-10, whereas a decrease in IL-6 levels suggested a complex mechanism of action. A more in-depth profile of macrophage behaviour was therefore obtained by comprehensive untargeted metabolic profiling of the cells using liquid chromatography mass spectrometry (LC-MS) to confirm the ability of the eicosanoids to trigger the immune system. The level of 358 polar and 315 non-polar metabolites were changed significantly (p < 0.05) by all treatments. The LPS-stimulated production of most of the inflammatory metabolite biomarkers in glycolysis, the tricarboxylic acid (TCA) cycle, the pentose phosphate pathway, purine, pyrimidine and fatty acids metabolism were significantly enhanced by all three compounds, and particularly by Methyl cis-11-eicosenoate and cis-11-eicosenoic acid. These findings support the proposed actions of (Z)-11-eicosenol, Methyl cis-11-eicosenoate and cis-11-eicosenoic acid as immune system stimulators.
