Home >> Research Area >>Natural Products>>Triterpenoids>> 7,8-Didehydrocimigenol

7,8-Didehydrocimigenol

CAS# 150972-72-8

7,8-Didehydrocimigenol

Catalog No. BCN3343----Order now to get a substantial discount!

Product Name & Size Price Stock
7,8-Didehydrocimigenol: 5mg Please Inquire In Stock
7,8-Didehydrocimigenol: 10mg Please Inquire In Stock
7,8-Didehydrocimigenol: 20mg Please Inquire Please Inquire
7,8-Didehydrocimigenol: 50mg Please Inquire Please Inquire
7,8-Didehydrocimigenol: 100mg Please Inquire Please Inquire
7,8-Didehydrocimigenol: 200mg Please Inquire Please Inquire
7,8-Didehydrocimigenol: 500mg Please Inquire Please Inquire
7,8-Didehydrocimigenol: 1000mg Please Inquire Please Inquire

Quality Control of 7,8-Didehydrocimigenol

Number of papers citing our products

Chemical structure

7,8-Didehydrocimigenol

3D structure

Chemical Properties of 7,8-Didehydrocimigenol

Cas No. 150972-72-8 SDF Download SDF
PubChem ID 101577840 Appearance Cryst.
Formula C30H46O5 M.Wt 486.7
Type of Compound Triterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CC1CC2C(OC3(C1C4(CCC56CC57CCC(C(C7CC=C6C4(C3O)C)(C)C)O)C)O2)C(C)(C)O
Standard InChIKey VFWGQUZLHBLDFF-OSIIPQMASA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 7,8-Didehydrocimigenol

The roots of Cimicifuga foetida L.

Biological Activity of 7,8-Didehydrocimigenol

Description1. 7,8-Didehydrocimigenol upregulates PPAR-γ in EC inhibits NF-kB activity of TNF-α-activated EC which leads to selective inhibition of VCAM-1 expression. 2. 7,8-Didehydrocimigenol can be used for the treatment of cardiovascular disorders such as atherosclerosis.
TargetsTNF-α | PPAR | NF-kB | ERK | Akt | IkB | IKK

7,8-Didehydrocimigenol Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

7,8-Didehydrocimigenol Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of 7,8-Didehydrocimigenol

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.0547 mL 10.2733 mL 20.5465 mL 41.0931 mL 51.3663 mL
5 mM 0.4109 mL 2.0547 mL 4.1093 mL 8.2186 mL 10.2733 mL
10 mM 0.2055 mL 1.0273 mL 2.0547 mL 4.1093 mL 5.1366 mL
50 mM 0.0411 mL 0.2055 mL 0.4109 mL 0.8219 mL 1.0273 mL
100 mM 0.0205 mL 0.1027 mL 0.2055 mL 0.4109 mL 0.5137 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on 7,8-Didehydrocimigenol

7,8-didehydrocimigenol from Cimicifugae rhizoma inhibits TNF-alpha-induced VCAM-1 but not ICAM-1expression through upregulation of PPAR-gamma in human endothelial cells.[Pubmed:20946932]

Food Chem Toxicol. 2011 Jan;49(1):166-72.

Activators of PPAR have been demonstrated to inhibit the induction of VCAM-1 but not ICAM-1 in human endothelial cells (EC). During the screening of anti-inflammatory activity of traditional herbs, we found 7,8-Didehydrocimigenol (7,8-DHC), one of active triterpenoids of Cimicifugae rhizoma (C. rhizoma) increases PPAR-gamma expression in EC in a time- and dose-dependent manner. Therefore, we asked whether 7,8-DHC selectively inhibits the expression of VCAM-1 but not ICAM-1 in TNF-alpha-activated EC via upregulation of PPAR-gamma. Treatment with 7,8-DHC or PPAR-gamma agonists (GW1929, troglitazone) inhibited the expression of VCAM-1 but not ICAM-1. Furthermore, the selective inhibition of VCAM-1 expression was inhibited by PPAR-gamma antagonist, GW9662, or siPPAR-gamma-transfected cells. 7,8-DHC significantly inhibited NF-kB activity via inhibition of phosphorylation of IkB and it also inhibited phosphorylation of ERK1/2 and Akt but not PKC. Finally, attachment of monocytes (U937) to EC by TNF-alpha was significantly reduced by 7,8-DHC. These results indicate that upregualtion of PPAR-gamma by 7,8-DHC in EC inhibits NF-kB activity of TNF-alpha-activated EC which leads to selective inhibition of VCAM-1 expression. In addition, ERK1/2 and Akt signal pathways are involved in differential regulation by 7,8-DHC. We concluded that 7,8-DHC can be used for the treatment of cardiovascular disorders such as atherosclerosis.

Keywords:

7,8-Didehydrocimigenol,150972-72-8,Natural Products, buy 7,8-Didehydrocimigenol , 7,8-Didehydrocimigenol supplier , purchase 7,8-Didehydrocimigenol , 7,8-Didehydrocimigenol cost , 7,8-Didehydrocimigenol manufacturer , order 7,8-Didehydrocimigenol , high purity 7,8-Didehydrocimigenol

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: