Home >> Research Area >>Coumarins>> 7,8-Dihydroxy-4-Methylcoumarin

7,8-Dihydroxy-4-Methylcoumarin

CAS# 2107-77-9

7,8-Dihydroxy-4-Methylcoumarin

Catalog No. BCC8290----Order now to get a substantial discount!

Product Name & Size Price Stock
7,8-Dihydroxy-4-Methylcoumarin: 5mg Please Inquire In Stock
7,8-Dihydroxy-4-Methylcoumarin: 10mg Please Inquire In Stock
7,8-Dihydroxy-4-Methylcoumarin: 20mg Please Inquire Please Inquire
7,8-Dihydroxy-4-Methylcoumarin: 50mg Please Inquire Please Inquire
7,8-Dihydroxy-4-Methylcoumarin: 100mg Please Inquire Please Inquire
7,8-Dihydroxy-4-Methylcoumarin: 200mg Please Inquire Please Inquire
7,8-Dihydroxy-4-Methylcoumarin: 500mg Please Inquire Please Inquire
7,8-Dihydroxy-4-Methylcoumarin: 1000mg Please Inquire Please Inquire

Quality Control of 7,8-Dihydroxy-4-Methylcoumarin

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Chemical structure

7,8-Dihydroxy-4-Methylcoumarin

3D structure

Chemical Properties of 7,8-Dihydroxy-4-Methylcoumarin

Cas No. 2107-77-9 SDF Download SDF
PubChem ID 5355836 Appearance Powder
Formula C10H8O4 M.Wt 192
Type of Compound Coumarins Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 7,8-dihydroxy-4-methylchromen-2-one
SMILES CC1=CC(=O)OC2=C1C=CC(=C2O)O
Standard InChIKey NWQBYMPNIJXFNQ-UHFFFAOYSA-N
Standard InChI InChI=1S/C10H8O4/c1-5-4-8(12)14-10-6(5)2-3-7(11)9(10)13/h2-4,11,13H,1H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 7,8-Dihydroxy-4-Methylcoumarin

The herbs of Daphne Korean Nakai

Biological Activity of 7,8-Dihydroxy-4-Methylcoumarin

Description1. 4-Methyldaphnetin is a potent inhibitor (low micromolar) of lipid peroxidation and scavengers of superoxide anion radicals and of aqueous alkylperoxyl radicals, but may be pro-oxidant (enhancing generation of hydroxyl radicals) in the presence of free iron ions. 2. 4-Methyldaphnetin inhibits the proinflammatory 5-lipoxygenase enzyme at micromolar concentrations.
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7,8-Dihydroxy-4-Methylcoumarin Dilution Calculator

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7,8-Dihydroxy-4-Methylcoumarin Molarity Calculator

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Preparing Stock Solutions of 7,8-Dihydroxy-4-Methylcoumarin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 5.2083 mL 26.0417 mL 52.0833 mL 104.1667 mL 130.2083 mL
5 mM 1.0417 mL 5.2083 mL 10.4167 mL 20.8333 mL 26.0417 mL
10 mM 0.5208 mL 2.6042 mL 5.2083 mL 10.4167 mL 13.0208 mL
50 mM 0.1042 mL 0.5208 mL 1.0417 mL 2.0833 mL 2.6042 mL
100 mM 0.0521 mL 0.2604 mL 0.5208 mL 1.0417 mL 1.3021 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 7,8-Dihydroxy-4-Methylcoumarin

Infrared, Raman and NMR spectra, conformational stability and vibrational assignment of 7,8-Dihydroxy-4-Methylcoumarin.[Pubmed:24935826]

Spectrochim Acta A Mol Biomol Spectrosc. 2014 Nov 11;132:871-8.

We report a combined some (infrared, Raman and NMR) spectroscopic and quantum chemistry study on 7,8-Dihydroxy-4-Methylcoumarin molecule (78D4MC). The Raman and IR spectra of 78D4MC molecule were recorded and analyzed in the region 3500-50 cm(-1) and 4000-400 cm(-1), respectively. Potential energy scans were performed at the MMFF level of theory. All possible conformers, which are results at the MMFF level theory, were re-computed at the B3LYP functional with cc-pVDZ basis set. The optimized geometrical parameters, harmonic vibrational wavenumbers and NMR chemical shifts of the most stable conformer were calculated at the B3LYP/6-311G(d,p), cc-pVTZ and cc-pVQZ level in the proximity of the isolated molecule. DFT calculations were combined with Pulay's scaled quantum mechanics force field (SQMFF) methodology in order to fit the theoretical wavenumbers to the experimental ones.

Description

4-Methyldaphnetin is a precursor in the synthesis of derivatives of 4-methyl coumarin. 4-Methyldaphnetin has potent, selective anti-proliferative and apoptosis-inducing effects on several cancer cell lines. 4-Methyldaphnetin possesses radical scavenging property and strongly inhibits membrane lipid peroxidation.

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