AgnusideCAS# 11027-63-7 |
Quality Control & MSDS
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| Cas No. | 11027-63-7 | SDF | Download SDF |
| PubChem ID | 442416 | Appearance | White powder |
| Formula | C22H26O11 | M.Wt | 466.4 |
| Type of Compound | Iridoids | Storage | Desiccate at -20°C |
| Synonyms | Buddlejoside A | ||
| Solubility | Soluble in ethanol, methanol and water | ||
| Chemical Name | [(1S,4aR,5S,7aS)-5-hydroxy-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-7-yl]methyl 4-hydroxybenzoate | ||
| SMILES | C1=COC(C2C1C(C=C2COC(=O)C3=CC=C(C=C3)O)O)OC4C(C(C(C(O4)CO)O)O)O | ||
| Standard InChIKey | GLACGTLACKLUJX-QNAXTHAFSA-N | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Agnuside has anti-arthritic activity, it also shows inhibition of vascular permeability and leukocyte migration in vivo.It inhibited an array of pro-inflammatory mediators (PGE(2) and LTB(4)) and T-cell-mediated cytokines (IL-2, TNF-α, IFN-γ, IL-4, IL-10, IL-17). |
| In vivo | Anti-arthritic activity of agnuside mediated through the down-regulation of inflammatory mediators and cytokines.[Pubmed: 22228102]Inflamm Res. 2012 Apr;61(4):293-304.The purpose of this study was to elucidate the probable mechanism for the anti-arthritic activity of Agnuside (AGN), a compound isolated from the leaf extract of Vitex negundo.
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| Animal Research | Anti-arthritic activity of agnuside mediated through the down-regulation of inflammatory mediators and cytokines.[Pubmed: 22228102]Inflamm Res. 2012 Apr;61(4):293-304.Animal Models: Fourteen-week-old Wistar rats (150–180 g) and 12-weekold Swiss albino mice (24–30 g) |
Agnuside Dilution Calculator
Agnuside Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.1441 mL | 10.7204 mL | 21.4408 mL | 42.8816 mL | 53.6021 mL |
| 5 mM | 0.4288 mL | 2.1441 mL | 4.2882 mL | 8.5763 mL | 10.7204 mL |
| 10 mM | 0.2144 mL | 1.072 mL | 2.1441 mL | 4.2882 mL | 5.3602 mL |
| 50 mM | 0.0429 mL | 0.2144 mL | 0.4288 mL | 0.8576 mL | 1.072 mL |
| 100 mM | 0.0214 mL | 0.1072 mL | 0.2144 mL | 0.4288 mL | 0.536 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Anti-arthritic activity of agnuside mediated through the down-regulation of inflammatory mediators and cytokines.[Pubmed:22228102]
Inflamm Res. 2012 Apr;61(4):293-304.
OBJECTIVE AND DESIGN: The purpose of this study was to elucidate the probable mechanism for the anti-arthritic activity of Agnuside (AGN), a compound isolated from the leaf extract of Vitex negundo. METHODOLOGY: The anti-inflammatory activity of AGN within a dose range of 1.56-12.50 mg/kg in normal and adrenalectomized rats was evaluated against different inflammagens. An array of pro-inflammatory mediators (PGE(2) and LTB(4)) and T-cell-mediated cytokines (IL-2, TNF-alpha, IFN-gamma, IL-4, IL-10, IL-17) was assayed using flow cytometry, in arthritic paw tissue homogenate and splenocytes of treated animals. RESULTS: Significant anti-arthritic activity was observed in the polyarthritis test in rats and this was associated with significant suppression of inflammatory mediators and T-cell-mediated cytokines (Th1/Th2). The anti-inflammatory activity in adrenalectomized rats confirmed that the effect of AGN is not mediated by the pituitary-adrenal axis. AGN also showed inhibition of vascular permeability and leukocyte migration in vivo. CONCLUSION: The study suggests the possible development of AGN as a therapeutic agent in the treatment of arthritis by the modulation of the host immune response.
