Cochliophilin ACAS# 110204-45-0 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 110204-45-0 | SDF | Download SDF |
| PubChem ID | 927642 | Appearance | Powder |
| Formula | C16H10O5 | M.Wt | 282 |
| Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 9-hydroxy-6-phenyl-[1,3]dioxolo[4,5-g]chromen-8-one | ||
| SMILES | C1OC2=C(O1)C(=C3C(=C2)OC(=CC3=O)C4=CC=CC=C4)O | ||
| Standard InChIKey | NJIUXIXNVAHRDW-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C16H10O5/c17-10-6-11(9-4-2-1-3-5-9)21-12-7-13-16(20-8-19-13)15(18)14(10)12/h1-7,18H,8H2 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Cochliophilin A, host-specific plant signal, triggers a dynamic polymerization/depolymerization of F-actin in pathogenic A. cochlioides zoospores during early events of plant-peronosporomycete interactions. 2. Cochliophilin A elicites attractant activity against the zoospores of the phytopathogenic Aphanomyces cochlioides. |
| Targets | Estrogen receptor | Progestogen receptor |
Cochliophilin A Dilution Calculator
Cochliophilin A Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.5461 mL | 17.7305 mL | 35.461 mL | 70.922 mL | 88.6525 mL |
| 5 mM | 0.7092 mL | 3.5461 mL | 7.0922 mL | 14.1844 mL | 17.7305 mL |
| 10 mM | 0.3546 mL | 1.773 mL | 3.5461 mL | 7.0922 mL | 8.8652 mL |
| 50 mM | 0.0709 mL | 0.3546 mL | 0.7092 mL | 1.4184 mL | 1.773 mL |
| 100 mM | 0.0355 mL | 0.1773 mL | 0.3546 mL | 0.7092 mL | 0.8865 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Phenolic constituents of Celosia cristata L. susceptible to spinach root rot pathogen Aphanomyces cochlioides.[Pubmed:17031042]
Biosci Biotechnol Biochem. 2006 Oct;70(10):2567-70.
Cochliophilin A (5-hydroxy-6,7-methylenedioxyflavone, 1), known as a host-specific attractant towards the zoospores of Aphanomyces cochlioides, a cause of root rot and damping-off diseases of Chenopodiaceae, was found in the Amaranthaceae plant, Celosia cristata, that is susceptible to the pathogen. The content of 1 in Celosia seedlings was quantified as 1.4 microg/g fresh weight. A new isoflavone, cristatein (5-hydroxy-6-hydroxymethyl-7,2'-dimethoxyisoflavone, 2), and five known flavonoids were also identified.
Dynamic rearrangement of F-actin organization triggered by host-specific plant signal is linked to morphogenesis of Aphanomyces cochlioides zoospores.[Pubmed:18412254]
Cell Motil Cytoskeleton. 2008 Jul;65(7):553-62.
Cochliophilin A (5-hydroxy-6,7-methylenedioxyflavone), a root releasing host-specific plant signal triggers chemotaxis and subsequent morphological changes in pathogenic Aphanomyces cochlioides zoospores before host penetration. The present study illustrates time-course changing patterns of cytoskeletal filamentous actin (F-actin) organization in the zoospores of A. cochlioides during rapid morphological changes (encystment and germination) after exposure to Cochliophilin A. Confocal laser scanning microscopic analysis revealed that F-actin microfilaments remained concentrated at ventral groove and diffusely distributed in peripheral cytoplasm of the zoospore. These microfilaments dramatically rearranged and changed into granular F-actin plaques interconnected with fine arrays during encystment. A large patch of actin arrays accumulated at one pole of the cystospores just before germination. Then the actin plaques moved to the emerging germ tube where a distinct cap of microfilaments was seen at the tip of the emerging hypha. Zoospores treated with an inhibitor of F-actin polymerization, latrunculin B or motility halting and regeneration inducing compound nicotinamide, displayed different patterns of F-actin in both zoospores and cystospores than those obtained by the induction of Cochliophilin A. Collectively, these results indicate that the host-specific plant signal Cochliophilin A triggers a dynamic polymerization/depolymerization of F-actin in pathogenic A. cochlioides zoospores during early events of plant-peronosporomycete interactions.
