AtroscineCAS# 138-12-5 |
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| Cas No. | 138-12-5 | SDF | Download SDF |
| PubChem ID | 6451257 | Appearance | Powder |
| Formula | C17H21NO4 | M.Wt | 303.36 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | CN1C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4 | ||
| Standard InChIKey | STECJAGHUSJQJN-QBMZJCKTSA-N | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The herbs of Atropa belladonna L.
| Description | 1. Atroscine has adrenolytic activity by its ability to antagonize the lethal effect of epinephrine in rats. |
| Targets | Adrenergic Receptor |
Atroscine Dilution Calculator
Atroscine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.2964 mL | 16.4821 mL | 32.9641 mL | 65.9283 mL | 82.4103 mL |
| 5 mM | 0.6593 mL | 3.2964 mL | 6.5928 mL | 13.1857 mL | 16.4821 mL |
| 10 mM | 0.3296 mL | 1.6482 mL | 3.2964 mL | 6.5928 mL | 8.241 mL |
| 50 mM | 0.0659 mL | 0.3296 mL | 0.6593 mL | 1.3186 mL | 1.6482 mL |
| 100 mM | 0.033 mL | 0.1648 mL | 0.3296 mL | 0.6593 mL | 0.8241 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Structure-activity requirements for hypotension and alpha-adrenergic receptor blockade by analogues of atropine.[Pubmed:6135619]
Eur J Pharmacol. 1983 May 20;90(1):75-83.
The hypotensive action of various antimuscarinic compounds structurally related to atropine was studied in conscious, unanesthetized rats. The alpha-adrenolytic activity of these agents was assessed both in vivo (blockade of norepinephrine-induced pressor response) and in vitro (displacement of [3H]WB-4101 binding). Benztropine, homatropine and hyoscyamine caused hypotension and produced alpha-adrenergic receptor blockade similar to atropine. Other analogues were either inactive (Atroscine, scopolamine, tropic acid and tropine) or evoked nonspecific changes in blood pressure and lacked alpha-adrenolytic activity (benactyzine, eucatropine, methylatropine, methylhomatropine and methylscopolamine). Based on these data, we propose the following structure-activity relationship for hypotension and alpha-adrenolytic activity: (a) the tropine moiety is inactive unless it is attached to another group by an ester linkage, (b) chemical modification of the tropine moiety, including quaternization, decreases potency, (c) the d-stereoisomer appears to be more potent than the corresponding 1-form.
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